Hajek P, Jarvis M J, Belcher M, Sutherland G, Feyerabend C
Institute of Psychiatry, London, UK.
Psychopharmacology (Berl). 1989;97(1):99-102. doi: 10.1007/BF00443421.
In a double-blind randomised trial, 40 cigarette smokers used either nicotine-containing or placebo smoke-free cigarettes during 24 h abstinence from smoking. Subjects in the nicotine group experienced smaller increases in irritability and difficulty concentrating and fewer urges to smoke than those who received placebo. Nicotine smoke-free cigarettes were rated as more satisfying, more helpful and more effective in relieving craving than placebo. After 24 h use nicotine smoke-free cigarettes provided average blood nicotine levels of 6.3 ng/ml, i.e., 29.2% of smoking levels. The most frequent side effects were irritation of the throat and coughing. Overall, side effects were rated as not serious. Although the smoke-free cigarette in its present form is not very efficient in delivering nicotine, it was effective in alleviating initial tobacco withdrawal. It is possible that by providing both nicotine and "behavioural" replacement it may be particularly useful in the first stages of stopping smoking. The product is worth further investigation.
在一项双盲随机试验中，40名吸烟者在戒烟24小时期间使用了含尼古丁或不含尼古丁的无烟香烟。与接受安慰剂的吸烟者相比，尼古丁组的吸烟者在易怒、注意力不集中方面的增加幅度较小，吸烟欲望也较少。与安慰剂相比，无烟尼古丁香烟在缓解烟瘾方面被评为更令人满意、更有帮助且更有效。使用24小时后，无烟尼古丁香烟的平均血液尼古丁水平为6.3纳克/毫升，即吸烟时尼古丁水平的29.2%。最常见的副作用是喉咙刺激和咳嗽。总体而言，副作用被评为不严重。虽然目前形式的无烟香烟在输送尼古丁方面效率不高，但它在缓解最初的烟草戒断症状方面是有效的。通过同时提供尼古丁和“行为”替代物，它在戒烟的第一阶段可能特别有用。该产品值得进一步研究。
