2013 年，墨西哥拉胡斯泰卡地区爆发 O1 群霍乱弧菌血清型 Ogawa、生物型 El Tor 菌株疫情。
Outbreak of Vibrio cholerae serogroup O1, serotype Ogawa, biotype El Tor strain--La Huasteca Region, Mexico, 2013.
出版信息
MMWR Morb Mortal Wkly Rep. 2014 Jun 27;63(25):552-3.
On September 2 and 6, 2013, Mexico's National System of Epidemiological Surveillance identified two cases of cholera in Mexico City. Rectal swab cultures from both patients were confirmed as toxigenic Vibrio cholerae serogroup O1, serotype Ogawa, biotype El Tor. Pulsed-field gel electrophoresis and virulence gene amplification (ctxA, ctxB, zot, and ace) demonstrated that the strains were identical to one another but different from strains circulating in Mexico previously. The strains were indistinguishable from the strain that has caused outbreaks in Haiti, the Dominican Republic, and Cuba. The strain was susceptible to doxycycline, had intermediate susceptibility to ampicillin and chloramphenicol, was less than fully susceptible to ciprofloxacin, and was resistant to furazolidone and trimethoprim-sulfamethoxazole. An investigation failed to identify a common source of infection, additional cases, or any epidemiologic link between the cases. Both patients were treated with a single, 300-mg dose of doxycycline, and their symptoms resolved.
2013 年 9 月 2 日和 6 日，墨西哥国家流行病学监测系统在墨西哥城发现了两例霍乱病例。两名患者的直肠拭子培养物均被确认为产毒性霍乱弧菌 O1 血清型 Ogawa、生物型 El Tor。脉冲场凝胶电泳和毒力基因扩增（ctxA、ctxB、zot 和 ace）表明，这些菌株彼此相同，但与墨西哥以前流行的菌株不同。这些菌株与在海地、多米尼加共和国和古巴引发疫情的菌株无法区分。该菌株对强力霉素敏感，对氨苄西林和氯霉素中度敏感，对环丙沙星的敏感性低于完全敏感，对呋喃唑酮和复方磺胺甲噁唑耐药。调查未能确定共同感染源、其他病例或病例之间的任何流行病学联系。两名患者均接受了单次 300 毫克剂量的强力霉素治疗，症状得到缓解。
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