de Mello Aline Haas, Gassenferth Aline, Schraiber Rosiane de Bona, Souza Luana da Rosa, Florentino Drielly, Danielski Lucinéia Gainski, Cittadin-Soares Evandro da Cruz, Fortunato Jucélia Jeremias, Petronilho Fabricia, Quevedo João, Rezin Gislaine Tezza
Laboratory of Clinical and Experimental Pathophysiology, Postgraduate Program in Health Sciences, Universidade do Sul de Santa Catarina, Av. José Acácio Moreira, 787, Tubarão, 88704-900, SC, Brazil.
Metab Brain Dis. 2014 Sep;29(3):691-9. doi: 10.1007/s11011-014-9577-5. Epub 2014 Jun 26.
Major depression is a heterogeneous psychiatric disorder whose pathophysiology is not clearly established yet. Some studies have shown that oxidative stress and mitochondrial dysfunction are involved in the development of major depression. Since most depressed patients do not achieve complete remission of symptoms, new therapeutic alternatives are needed and omega-3 has been highlighted in this scenario. Therefore, we have investigated the effects of omega-3 on behavioral and biochemical parameters in rats submitted to chronic mild stress (CMS). Male Wistar rats were submitted to CMS for 40 days. After the CMS period, we administered a 500 mg/kg dose of omega-3 orally, once a day, for 7 days. The animals submitted to CMS presented anhedonia, had no significant weight gain, presented increased levels of lipid peroxidation and protein carbonylation, and inhibition of complex I and IV activities of the mitochondrial respiratory chain. The treatment with omega-3 did not reverse anhedonia; however, it reversed weight change, increased lipid peroxidation and protein carbonylation levels, and partially reversed the inhibition of mitochondrial respiratory chain complexes. The findings support studies that state that major depression is associated with mitochondrial dysfunction and oxidative stress, and that omega-3 supplementation could reverse some of these changes, probably due to its antioxidant properties.
重度抑郁症是一种异质性精神障碍，其病理生理学尚未明确确立。一些研究表明，氧化应激和线粒体功能障碍与重度抑郁症的发生有关。由于大多数抑郁症患者症状无法完全缓解，因此需要新的治疗选择，在这种情况下，ω-3脂肪酸受到了关注。因此，我们研究了ω-3脂肪酸对接受慢性轻度应激（CMS）的大鼠行为和生化参数的影响。雄性Wistar大鼠接受40天的CMS。在CMS期后，我们每天口服一次500mg/kg剂量的ω-3脂肪酸，持续7天。接受CMS的动物出现快感缺失，体重没有显著增加，脂质过氧化和蛋白质羰基化水平升高，线粒体呼吸链复合体I和IV的活性受到抑制。ω-3脂肪酸治疗并未逆转快感缺失；然而，它逆转了体重变化，提高了脂质过氧化和蛋白质羰基化水平，并部分逆转了线粒体呼吸链复合体的抑制。这些发现支持了以下研究结果，即重度抑郁症与线粒体功能障碍和氧化应激有关，补充ω-3脂肪酸可能因其抗氧化特性而逆转其中一些变化。
