Zhang Shulong, Tao Wang Hong
Department of General Surgery, Zhongda Hospital, Southeast University Medical School, Nanjing, Jiangsu, China.
J BUON. 2014 Apr-Jun;19(2):567-72.
A number of studies have investigated the association between human leukocyte antigen-G (HLA-G) 14-bp insertion/deletion polymorphism and cancer risk, but the results remain controversial. In this study we aimed to clarify whether this association really exists.
We carried out a meta-analysis of 8 studies including 1179 cases and 2795 controls from PubMed and Chinese language (CNKI and WanFang) databases to assess the association between the HLA-G 14-bp insertion/deletion polymorphism and cancer risk by pooled odds ratio (OR) and 95% confidence interval (CI).
The results showed that the HLA-G 14-bp insertion/ deletion polymorphism was not associated with total cancer risk in all genetic models (dominant model: OR=0.90, 95% CI-0.70-1.17; recessive model: OR=0.97, 95% CI=0.67-1.42; insertion/deletion (ID) vs deletion/deletion (DD):OR=0.88, 95% CI=0.66-1.18; insertion/insertion (II) vs DD: OR=0.94, 95% CI=0.62-1.41; insertion (I) vs deletion (D): OR=0.95, 95% CI=0.78-1.16). In the subgroup analysis by ethnicity, no significant association was found between Asians and Caucasians. However, subgroup analysis by cancer type showed that the polymorphism was associated with risk of hepatocellular carcinoma.
This meta-analysis suggests that HLA-G 14-bp insertion/deletion polymorphism may not influence the susceptibility of total cancer, but it is related to risk of hepatocellular carcinoma.
多项研究探讨了人类白细胞抗原-G（HLA-G）14碱基对插入/缺失多态性与癌症风险之间的关联，但结果仍存在争议。本研究旨在明确这种关联是否真的存在。
我们对来自PubMed以及中文数据库（中国知网和万方）的8项研究进行了荟萃分析，这些研究包括1179例病例和2795例对照，通过合并比值比（OR）和95%置信区间（CI）来评估HLA-G 14碱基对插入/缺失多态性与癌症风险之间的关联。
结果显示，在所有遗传模型中，HLA-G 14碱基对插入/缺失多态性与总体癌症风险均无关联（显性模型：OR = 0.90，95% CI = 0.70 - 1.17；隐性模型：OR = 0.97，95% CI = 0.67 - 1.42；插入/缺失（ID）与缺失/缺失（DD）：OR = 0.88，95% CI = 0.66 - 1.18；插入/插入（II）与DD：OR = 0.94，95% CI = 0.62 - 1.41；插入（I）与缺失（D）：OR = 0.95，95% CI = 0.78 - 1.16）。按种族进行的亚组分析显示，亚洲人和高加索人之间未发现显著关联。然而，按癌症类型进行的亚组分析表明，该多态性与肝细胞癌风险相关。
这项荟萃分析表明，HLA-G 14碱基对插入/缺失多态性可能不会影响总体癌症易感性，但与肝细胞癌风险有关。
