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Indomethacin stimulation of macrophage cytostasis against MOPC-315 tumor cells is enhanced by endogenous metabolites of lipoxygenase and counteracted by prostaglandin E2.

作者信息

Bonta I L, Elliott G R, Tak C, Ben-Efraim S

机构信息

Department of Pharmacology, Medical Faculty, Erasmus University, Rotterdam, The Netherlands.

出版信息

Agents Actions. 1989 Jan;26(1-2):167-9. doi: 10.1007/BF02126596.

DOI:10.1007/BF02126596
PMID:2496587
Abstract
摘要

相似文献

1
Indomethacin stimulation of macrophage cytostasis against MOPC-315 tumor cells is enhanced by endogenous metabolites of lipoxygenase and counteracted by prostaglandin E2.消炎痛对巨噬细胞抑制MOPC - 315肿瘤细胞生长的刺激作用可被脂氧合酶的内源性代谢产物增强，并被前列腺素E2抵消。
Agents Actions. 1989 Jan;26(1-2):167-9. doi: 10.1007/BF02126596.
2
Indomethacin stimulation of macrophage cytostasis against MOPC-315 tumor cells is inhibited by both prostaglandin E2 and nordihydroguaiaretic acid, a lipoxygenase inhibitor.吲哚美辛对巨噬细胞抑制MOPC - 315肿瘤细胞作用的刺激，受到前列腺素E2和脂氧合酶抑制剂去甲二氢愈创木酸的抑制。
Cancer Immunol Immunother. 1988;27(2):133-6. doi: 10.1007/BF00200017.
3
Endogenous lipoxygenase metabolites mediate A23187 induced macrophage cytostasis towards P815 tumor cells in vitro.内源性脂氧合酶代谢产物介导A23187在体外诱导巨噬细胞对P815肿瘤细胞的细胞停滞作用。
Agents Actions. 1989 Jan;26(1-2):170-2. doi: 10.1007/BF02126597.
4
Opposing effects of indomethacin and nordihydroguaiaretic acid on macrophage function and tumor growth.消炎痛与去甲二氢愈创木酸对巨噬细胞功能及肿瘤生长的相反作用。
Jpn J Cancer Res. 1994 Mar;85(3):306-14. doi: 10.1111/j.1349-7006.1994.tb02098.x.
5
Regulation of macrophage-derived fibroblast growth factor release by arachidonate metabolites.花生四烯酸代谢产物对巨噬细胞衍生的成纤维细胞生长因子释放的调节
J Leukoc Biol. 1987 Aug;42(2):106-13. doi: 10.1002/jlb.42.2.106.
6
Endothelial cell proliferation may be mediated via the production of endogenous lipoxygenase metabolites.内皮细胞增殖可能通过内源性脂氧合酶代谢产物的产生来介导。
Biochem Biophys Res Commun. 1987 Apr 14;144(1):345-51. doi: 10.1016/s0006-291x(87)80516-8.
7
An in vitro study of the effect of lipoxygenase and cyclo-oxygenase inhibitors of arachidonic acid on the induction and maintenance of long-term potentiation in the hippocampus.花生四烯酸的脂氧合酶和环氧化酶抑制剂对海马体中长时程增强的诱导和维持作用的体外研究。
Neurosci Lett. 1989 Dec 15;107(1-3):301-6. doi: 10.1016/0304-3940(89)90835-5.
8
Cytostatic and cytolytic activities of macrophages regulation by prostaglandins.前列腺素对巨噬细胞的细胞抑制和细胞溶解活性的调节
Cell Immunol. 1984 Jan;83(1):34-42. doi: 10.1016/0008-8749(84)90222-3.
9
Inhibitors of lipoxygenase have antiproliferative effects on P815 murine mastocytoma cells.脂氧合酶抑制剂对P815小鼠肥大细胞瘤细胞具有抗增殖作用。
Cancer Lett. 1990 Mar;49(3):181-5. doi: 10.1016/0304-3835(90)90156-r.
10
[Growth inhibition and induction of tumor cell death by phospholipase A2 and lipoxygenase inhibitors].
Izv Akad Nauk Ser Biol. 2001 Mar-Apr(2):249-52.

引用本文的文献

1
Interactions between rnacrophage cytokines and eicosanoids in expression of antitumour activity.巨噬细胞细胞因子与类花生酸在抗肿瘤活性表达中的相互作用。
Mediators Inflamm. 1992;1(5):295-308. doi: 10.1155/S0962935192000449.
2
In vivo indomethacin treatment causes microglial activation in adult mice.体内给予吲哚美辛会导致成年小鼠的小胶质细胞激活。
Neurochem Res. 2000 Mar;25(3):357-62. doi: 10.1023/a:1007588903897.

本文引用的文献

1
In vitro effect of levan-activated macrophages on Lewis lung carcinoma cells.左聚糖激活的巨噬细胞对Lewis肺癌细胞的体外作用。
Int J Immunopharmacol. 1986;8(5):471-8. doi: 10.1016/0192-0561(86)90042-1.
2
Leukotriene D4 and indomethacin enhance additively the macrophage cytostatic activity in vitro towards MOPC-315 tumour cells.白三烯D4和消炎痛在体外对MOPC - 315肿瘤细胞的巨噬细胞抑制活性有相加增强作用。
Int J Tissue React. 1987;9(3):189-94.
3
Cyclooxygenase inhibitors promote the leukotriene C4 induced release of beta-glucuronidase from rat peritoneal macrophages: prostaglandin E2 suppresses.
Int J Immunopharmacol. 1986;8(3):305-11. doi: 10.1016/0192-0561(86)90112-8.
4
Leukotrienes augment interleukin 1 production by human monocytes.白三烯可增强人单核细胞白细胞介素1的产生。
J Immunol. 1985 Dec;135(6):3958-61.
5
Indomethacin increases the formation of lipoxygenase products in calcium ionophore stimulated human neutrophils.吲哚美辛可增加钙离子载体刺激的人中性粒细胞中脂氧合酶产物的生成。
Biochem Biophys Res Commun. 1987 Oct 29;148(2):534-8. doi: 10.1016/0006-291x(87)90909-0.