猫的曲马多中毒：血清素综合征的病例报告及文献综述
Tramadol toxicity in a cat: case report and literature review of serotonin syndrome.
作者信息
Indrawirawan Yenny, McAlees Trudi
机构信息
Animal Accident and Emergency, Melbourne, Victoria, Australia
Animal Accident and Emergency, Melbourne, Victoria, Australia.
出版信息
J Feline Med Surg. 2014 Jul;16(7):572-8. doi: 10.1177/1098612X14539088.
Abstract
OVERVIEW
Tramadol toxicity has not previously been reported in a cat.
CASE SUMMARY
This report describes the clinical signs, diagnosis and treatment of tramadol toxicity, manifesting as serotonin syndrome, in a cat in Australia.
PRACTICAL RELEVANCE
For any cat with suspicion of serotonin syndrome, in particular secondary to tramadol overdose, it is recommended that decontamination, monitoring and supportive care are instituted as soon as clinical signs develop. Prolonged hospitalisation may be required in the event of a severe overdose.
LITERATURE REVIEW
The literature relating to the pharmacology of tramadol and tramadol overdose, clinical manifestations of tramadol overdose, and serotonin syndrome in cats, humans and dogs is reviewed. Recommended treatment for tramadol overdose and serotonin syndrome is also discussed.
摘要
概述
此前尚未有猫出现曲马多中毒的报道。
病例摘要
本报告描述了澳大利亚一只猫出现曲马多中毒（表现为血清素综合征）的临床症状、诊断及治疗情况。
实际意义
对于任何疑似血清素综合征的猫，尤其是继发于曲马多过量的情况，建议一旦出现临床症状，立即进行去污、监测及支持性护理。若过量情况严重，可能需要延长住院时间。
文献综述
回顾了有关曲马多药理学、曲马多过量、猫、人和犬曲马多过量的临床表现以及血清素综合征的文献。还讨论了曲马多过量及血清素综合征的推荐治疗方法。
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