Sillar Keith T, Combes Denis, Simmers John
School of Psychology and Neuroscience, University of St Andrews, Westburn Lane, St Andrews, Fife KY16 9JP, Scotland, UK.
Université de Bordeaux, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, CNRS Unité Mixte de Recherche 5287, 146 rue Léo Saignat, 33076 Bordeaux, France.
Curr Opin Neurobiol. 2014 Dec;29:73-81. doi: 10.1016/j.conb.2014.05.009. Epub 2014 Jun 24.
Neuromodulation confers operational flexibility on motor network output and resulting behaviour. Furthermore, neuromodulators play crucial long-term roles in the assembly and maturational shaping of the same networks as they develop. Although previous studies have identified such modulator-dependent contributions to microcircuit ontogeny, some of the underlying mechanisms are only now being elucidated. Deciphering the role of neuromodulatory systems in motor network development has potentially important implications for post-lesional regenerative strategies in adults.
神经调节赋予运动网络输出及由此产生的行为以操作灵活性。此外，神经调质在相同网络发育过程中的组装和成熟塑造中发挥着关键的长期作用。尽管先前的研究已经确定了这种依赖于调质的对微电路个体发生的贡献，但一些潜在机制直到现在才被阐明。解读神经调节系统在运动网络发育中的作用对成人损伤后的再生策略具有潜在的重要意义。
