Unidad de Biotecnología Industrial, CIATEJ, A.C. Av. Normalistas 800, Col. Colinas de la Normal, Guadalajara, Jal, C.P. 44270, Mexico.
Biomolecules. 2013 Oct 17;3(4):812-47. doi: 10.3390/biom3040812.
The design and development of greener processes that are safe and friendly is an irreversible trend that is driven by sustainable and economic issues. The use of Biocatalysis as part of a manufacturing process fits well in this trend as enzymes are themselves biodegradable, require mild conditions to work and are highly specific and well suited to carry out complex reactions in a simple way. The growth of computational capabilities in the last decades has allowed Biocatalysis to develop sophisticated tools to understand better enzymatic phenomena and to have the power to control not only process conditions but also the enzyme's own nature. Nowadays, Biocatalysis is behind some important products in the pharmaceutical, cosmetic, food and bulk chemicals industry. In this review we want to present some of the most representative examples of industrial chemicals produced in vitro through enzymatic catalysis.
绿色工艺的设计和开发是受到可持续性和经济性问题驱动的、安全且友好的不可逆转趋势。将生物催化作为制造工艺的一部分是符合这一趋势的，因为酶本身是可生物降解的，在温和的条件下就能发挥作用，具有高度的特异性，非常适合以简单的方式进行复杂反应。过去几十年中计算能力的增长使生物催化能够开发出更复杂的工具来更好地理解酶现象，并具有不仅控制工艺条件，而且控制酶自身性质的能力。如今，生物催化在制药、化妆品、食品和大宗化学品等行业的一些重要产品背后发挥着作用。在这篇综述中，我们想介绍一些通过酶催化在体外生产的具有代表性的工业化学品的实例。
