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老年患者良性前肠疾病手术治疗效果:国家手术质量改进计划数据库分析。

Outcomes of operations for benign foregut disease in elderly patients: a National Surgical Quality Improvement Program database analysis.

机构信息

Division of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

Division of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

出版信息

Surgery. 2014 Aug;156(2):352-60. doi: 10.1016/j.surg.2014.04.005. Epub 2014 Jun 25.

Abstract

BACKGROUND

The development of minimally invasive operative techniques and improvement in postoperative care has made surgery a viable option to a greater number of elderly patients. Our objective was to evaluate the outcomes of laparoscopic and open foregut operation in relation to the patient age.

METHODS

Patients who underwent gastric fundoplication, paraesophageal hernia repair, and Heller myotomy were identified via the National Surgical Quality Improvement Program (NSQIP) database (2005-2011). Patient characteristics and outcomes were compared between five age groups (group I: ≤65 years, II: 65-69 years; III: 70-74 years; IV: 75-79 years; and V: ≥80 years). Multivariable logistic regression analysis was used to predict the impact of age and operative approach on the studied outcomes.

RESULTS

A total of 19,388 patients were identified. Advanced age was associated with increased rate of 30-day mortality, overall morbidity, serious morbidity, and extended length of stay, regardless of the operative approach. After we adjusted for other variables, advanced age was associated with increased odds of 30-day mortality compared with patients <65 years (III: odds ratio 2.70, 95% confidence interval 1.34-5.44, P = .01; IV: 2.80, 1.35-5.81, P = .01; V: 6.12, 3.41-10.99, P < .001).

CONCLUSION

Surgery for benign foregut disease in elderly patients carries a burden of mortality and morbidity that needs to be acknowledged.

摘要

背景

微创手术技术的发展和术后护理的改善,使更多老年患者能够接受手术治疗。我们的目的是评估腹腔镜和开腹上消化道手术与患者年龄的关系。

方法

通过国家外科质量改进计划(NSQIP)数据库(2005-2011 年)确定接受胃底折叠术、食管裂孔疝修补术和 Heller 肌切开术的患者。比较五个年龄组(I 组:≤65 岁;II 组:65-69 岁;III 组:70-74 岁;IV 组:75-79 岁;V 组:≥80 岁)的患者特征和结局。采用多变量逻辑回归分析预测年龄和手术方式对研究结果的影响。

结果

共确定了 19388 例患者。无论手术方式如何,高龄与 30 天死亡率、总发病率、严重发病率和延长住院时间的发生率增加有关。在调整其他变量后,与<65 岁的患者相比,高龄与 30 天死亡率增加有关(III 组:比值比 2.70,95%置信区间 1.34-5.44,P=0.01;IV 组:2.80,1.35-5.81,P=0.01;V 组:6.12,3.41-10.99,P<0.001)。

结论

老年患者良性上消化道疾病的手术治疗存在死亡和发病的风险,需要引起重视。

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