Ustyuzhanina Nadezhda E, Bilan Maria I, Ushakova Natalia A, Usov Anatolii I, Kiselevskiy Mikhail V, Nifantiev Nikolay E
Laboratory of Glycoconjugate Chemistry.
Laboratory of Plant Polysaccharides, N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prospect 47, Moscow 119991, Russia.
Glycobiology. 2014 Dec;24(12):1265-74. doi: 10.1093/glycob/cwu063. Epub 2014 Jun 27.
Sulfated polysaccharides of brown algae (fucoidans) attract great attention due to their high and strongly diversified biological activity. This review summarizes recent data on the structural variability of these polysaccharides and reports their anti- and proangiogenic properties. Recent publications have revealed that fucoidans isolated from different algal species may differ considerably in the structures of their backbones and branches, in both monosaccharide composition and sulfate content. It was found that the degree of sulfation significantly influences the biological properties of fucoidans. Additionally, fucoidan action in angiogenesis is highly dependent on molecular weight: antiangiogenic activity is connected with the high-molecular weight of polysaccharide molecules, whereas the low-molecular-weight fractions may act as proangiogenic agents. The influence of other fine structural details of fucoidans on angiogenesis remains to be established.
褐藻硫酸化多糖（岩藻聚糖）因其高度且极为多样的生物活性而备受关注。本综述总结了关于这些多糖结构变异性的最新数据，并报道了它们的抗血管生成和促血管生成特性。最近的出版物表明，从不同藻类物种中分离出的岩藻聚糖在其主链和支链结构、单糖组成以及硫酸盐含量方面可能存在显著差异。研究发现，硫酸化程度对岩藻聚糖的生物学特性有显著影响。此外，岩藻聚糖在血管生成中的作用高度依赖于分子量：抗血管生成活性与多糖分子的高分子量相关，而低分子量部分可能作为促血管生成剂。岩藻聚糖其他精细结构细节对血管生成的影响仍有待确定。
