School of Population Health, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia.
Harry Perkins Institute for Medical Research, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia.
Sci Total Environ. 2014 Sep 15;493:554-61. doi: 10.1016/j.scitotenv.2014.06.001. Epub 2014 Jun 27.
PBDEs are a class of brominated flame retardants applied to consumer goods to reduce their flammability. These compounds are lipophilic, persistent and bioaccumulate through the food web. PBDEs have been detected in human blood, adipose tissue and breast milk. There are a small number of studies reporting concentrations of PBDEs in Australian populations. These indicate that concentrations are higher than in studies reporting concentrations from Europe but lower than those from Northern America. The aim of this paper was to determine the concentrations of PBDEs in the plasma of pregnant women participating in the Australian Maternal Exposure to Toxic Substances (AMETS) study in Western Australia. The samples comprised 164 pregnant women, aged 18 years and over, who were non-smokers and not occupationally exposed to persistent substances. Participants provided blood samples at 38 weeks gestation and these were analysed for five PBDE congeners. Maternal health and birth outcomes data were also obtained. The median for sum PBDE concentrations in plasma was 53.9 pg g(-1) (range 13.2 to 1390 pg g(-1)ww). Concentrations were adjusted for the estimated plasma lipid content. The concentrations of Σ5PBDE ranged from 2.44 to 258 ng g(-1) lipid with a median of 9.97 ng g(-1) lipid. BDE-47 was the dominant congener (median 21.4 pg g(-1), range <4.95 to 1030 pg g(-1)) followed by BDE-153 (median 12.2 pg g(-1), range <2.94 to 353 pg g(-1)). There were no significant associations between maternal, housing or dietary factors and concentrations of PBDEs in this study. Maternal PBDE concentrations were not associated with infant birth weight. This study builds upon previous Australian research and shows that concentrations in this sample of Western Australian women were higher than in parts of Europe.
多溴联苯醚是一类溴化阻燃剂，应用于消费品以降低其可燃性。这些化合物具有亲脂性、持久性，并通过食物网进行生物累积。多溴联苯醚已在人体血液、脂肪组织和母乳中被检测到。有少量研究报告了澳大利亚人群中多溴联苯醚的浓度。这些研究表明，澳大利亚的浓度高于报告来自欧洲浓度的研究，但低于来自北美的研究。本文的目的是确定参加澳大利亚母体接触有毒物质（AMETS）研究的西澳大利亚孕妇血浆中多溴联苯醚的浓度。该样本包括 164 名年龄在 18 岁及以上的孕妇，她们不吸烟，也没有职业性接触持久性物质。参与者在妊娠 38 周时提供血液样本，这些样本用于分析 5 种多溴联苯醚同系物。还获得了产妇健康和出生结局数据。血浆中多溴联苯醚总浓度的中位数为 53.9pg g(-1)（范围 13.2 至 1390pg g(-1)ww）。浓度根据估计的血浆脂质含量进行了调整。Σ5PBDE 的浓度范围为 2.44 至 258ng g(-1)脂质，中位数为 9.97ng g(-1)脂质。BDE-47 是主要的同系物（中位数 21.4pg g(-1)，范围 <4.95 至 1030pg g(-1)），其次是 BDE-153（中位数 12.2pg g(-1)，范围 <2.94 至 353pg g(-1)）。在这项研究中，母体、住房或饮食因素与多溴联苯醚浓度之间没有显著关联。母体多溴联苯醚浓度与婴儿出生体重无关。本研究建立在以前的澳大利亚研究基础上，表明该样本中来自西澳大利亚妇女的浓度高于欧洲部分地区。
