College of Biological Resources and Environment Science, Qujing Normal University, Qujing 655011, PR China.
Fitoterapia. 2012 Jan;83(1):55-9. doi: 10.1016/j.fitote.2011.09.009. Epub 2011 Sep 24.
Four new taraxerane triterpenoids, 1β,3β-dihydroxy-11α,12α-oxidotaraxerane (1), 28-hydroxy-11α,12α-oxidotaraxerane-3-one (2), 3β-hydroxy-11α,12α-oxidotaraxerane-28-al (3), and 3-O-acetyl-11α,12α-oxidotaraxerane-28-al (4), together with three known compounds 3β-hydroxy-11α,12α-oxidotaraxerane (5), 3β,28-dihydroxy-11α,12α-oxidotaraxerane (6), and 11α,12α-oxidotaraxerane-3-one (7), were isolated from the 70% EtOH extract of Saussurea graminea. Their structures were elucidated on the basis of extensive 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) analyses. The isolated compounds were evaluated in vitro for cytotoxic properties against eight tumor cell lines (A-549, BGC-823, HCT15, HeLa, HepG2, MCF-7, SGC-7901 and SK-MEL-2).
四种新的蒲公英萜烷三萜类化合物，1β,3β-二羟基-11α,12α-氧化蒲公英萜烷（1）、28-羟基-11α,12α-氧化蒲公英萜烷-3-酮（2）、3β-羟基-11α,12α-氧化蒲公英萜烷-28-醛（3）和 3-O-乙酰基-11α,12α-氧化蒲公英萜烷-28-醛（4），以及三种已知化合物 3β-羟基-11α,12α-氧化蒲公英萜烷（5）、3β,28-二羟基-11α,12α-氧化蒲公英萜烷（6）和 11α,12α-氧化蒲公英萜烷-3-酮（7），从甘青蒲公英的 70%EtOH 提取物中分离得到。根据广泛的 1D 和 2D NMR（COSY、HMQC、HMBC 和 NOESY）分析，确定了它们的结构。对分离得到的化合物进行了体外抗肿瘤活性评价，针对八种肿瘤细胞系（A-549、BGC-823、HCT15、HeLa、HepG2、MCF-7、SGC-7901 和 SK-MEL-2）。
