Kim Yong-Dae, Yim Dong-Hyuk, Eom Sang-Yong, Moon Sun-In, Park Choong-Hee, Kim Guen-Bae, Yu Seung-Do, Choi Byung-Sun, Park Jung-Duck, Kim Heon
Department of Preventive Medicine and Medical Research Institute, College of Medicine, Chungbuk National University, Cheongju, Chungbuk 361-763, Republic of Korea.
Environmental Health Research Division, Environmental Health Research Department, National Institute of Environmental Research, Incheon 404-708, Republic of Korea.
Environ Toxicol Pharmacol. 2014 Jul;38(1):272-8. doi: 10.1016/j.etap.2014.06.002. Epub 2014 Jun 13.
This study aimed to estimate the risks for renal tubular damage and osteoporosis in individuals with long-term environmental Cd exposure. This cross-sectional study comprised 1086 residents living in the vicinity of a copper refinery plant. As the urinary Cd levels increased, the proportion of female subjects with β₂-MG ≥300 μg/g creatinine also increased significantly, but this was not observed in the male subjects. The prevalence of osteoporosis was significantly higher in men with urinary Cd >5 μg/g creatinine than in those with urinary Cd ≤5 μg/g creatinine. This difference was not observed in the corresponding female groups. The association between increased urinary excretion of β₂-MG and decreased BMD was statistically significant only in the female subjects. We suggest that an increased Cd body burden directly decreases the BMD in male subjects; however, in female subjects, it first induces renal microtubular damage, which can lead to osteoporosis.
本研究旨在评估长期暴露于环境镉中的个体发生肾小管损伤和骨质疏松症的风险。这项横断面研究纳入了1086名居住在铜冶炼厂附近的居民。随着尿镉水平的升高，β₂-微球蛋白≥300μg/g肌酐的女性受试者比例也显著增加，但男性受试者未观察到这种情况。尿镉>5μg/g肌酐的男性骨质疏松症患病率显著高于尿镉≤5μg/g肌酐的男性。相应的女性组未观察到这种差异。仅在女性受试者中，β₂-微球蛋白尿排泄增加与骨密度降低之间的关联具有统计学意义。我们认为，镉体内负荷增加直接降低男性受试者的骨密度；然而，在女性受试者中，它首先诱发肾微管损伤，进而导致骨质疏松症。
