Pin D, Bekrich M, Fantini O, Noel G, Vidémont E
Interactions Cellules Environnement UPSP 2011.03.101, Unité Dermatologie, Laboratoire de Dermatopathologie, VetAgro Sup Campus Vétérinaire de Lyon, Marcy l'Etoile F-69280, France.
VetAgro Sup Campus Vétérinaire de Lyon Marcy l'Etoile F-69280, France.
J Comp Pathol. 2014 Aug-Oct;151(2-3):244-54. doi: 10.1016/j.jcpa.2014.04.009. Epub 2014 Jun 26.
The aim of this study was to investigate the effect of Douxo(®) Calm Mousse (Sogeval, Laval, France) on restoration of the skin barrier in a canine model of barrier disruption. Tape strips were performed, daily for 6 days, on the lateral thorax of five healthy beagle dogs. Douxo(®) Calm Mousse was applied daily for 5 days to one side of the thorax and the opposite side was left untreated. The effects of treatment were evaluated by measurement of transepidermal water loss (TEWL) and pH and by histological assessment of disrupted skin at various times during barrier repair. Although no effect on TEWL was observed, Douxo(®) Calm Mousse maintained an acidic pH after three applications and reduced skin inflammation, which was most pronounced after five applications. The results of the study suggest that Douxo(®) Calm Mousse exerts a beneficial effect on barrier restoration and on markers of inflammation.
本研究的目的是在屏障破坏的犬类模型中，研究Douxo（®）舒缓慕斯（法国拉瓦尔索热瓦尔公司）对皮肤屏障修复的影响。对5只健康的比格犬的侧胸部每天进行胶带剥离，持续6天。将Douxo（®）舒缓慕斯每天涂抹于胸部一侧，持续5天，另一侧不进行处理。在屏障修复过程中的不同时间，通过测量经表皮水分流失（TEWL）和pH值以及对受损皮肤进行组织学评估来评价治疗效果。虽然未观察到对TEWL有影响，但Douxo（®）舒缓慕斯在涂抹三次后维持了酸性pH值，并减轻了皮肤炎症，在涂抹五次后最为明显。研究结果表明，Douxo（®）舒缓慕斯对屏障修复和炎症标志物具有有益作用。
