VetAgro Sup, UP ICE, Université de Lyon, 69280, Marcy l'Étoile, France.
Centre Hospitalier Vétérinaire Saint-Martin, 74370, Saint-Martin-de-Bellevue, France.
Vet Dermatol. 2020 Oct;31(5):344-e89. doi: 10.1111/vde.12859. Epub 2020 Jul 6.
Moisturizers are foundational therapies for human atopic dermatitis. In veterinary medicine, the use of moisturizers has been recommended by an expert committee to alleviate skin dryness that would occur, for example, in canine atopic dermatitis (cAD). However, little is known regarding the effects of moisturizers on the skin barrier.
HYPOTHESIS/OBJECTIVES: To investigate the effects of a moisturizer on skin barrier recovery in a canine model of chronic mechanical barrier disruption.
Six healthy beagle dogs maintained in a laboratory setting.
A model of chronic skin barrier disruption was simulated by tape stripping on both sides of the thorax. The moisturizer then was applied twice daily for one week to one side of the thorax, while the other hemithorax was left untreated. The effects were evaluated by measurement of transepidermal water loss (TEWL) at various times during skin barrier recovery, and by histological assessment of the disrupted skin one week after moisturizer application.
Overall, TEWL was reduced, epidermal thickness was lower, stratum corneum thickness was greater and the intensity of the dermal inflammatory infiltrate was reduced for treated sites.
These results suggest a potential benefit of the moisturizer for improving skin barrier function, which is frequently altered in chronic inflammatory dermatoses such as cAD.
保湿剂是人类特应性皮炎的基础治疗方法。在兽医领域，一个专家委员会建议使用保湿剂来缓解皮肤干燥，例如犬特应性皮炎（cAD）中就会出现皮肤干燥。然而，关于保湿剂对皮肤屏障的影响知之甚少。
假设/目的：研究保湿剂对慢性机械性屏障破坏犬模型皮肤屏障恢复的影响。
6 只在实验室环境中饲养的健康比格犬。
通过在胸部两侧进行胶带撕脱模拟慢性皮肤屏障破坏模型。然后，在一侧胸部每天应用两次保湿剂，持续一周，而另一侧则不进行处理。通过在皮肤屏障恢复过程中的不同时间测量经皮水分丢失（TEWL），以及在保湿剂应用一周后评估受损皮肤的组织学，来评估效果。
总的来说，TEWL 降低，表皮厚度降低，角质层厚度增加，真皮炎症浸润强度降低。
这些结果表明保湿剂具有改善皮肤屏障功能的潜力，这在犬特应性皮炎等慢性炎症性皮肤病中经常发生改变。
