El Mouzan Mohammad I, Al Mofarreh Mohammed A, Assiri Asaad M, Hamid Yassin H, Al Jebreen Abdulrahman M, Azzam Nahla A
Department of Pediatrics, Gastroenterology Division, King Saud University, PO Box 2925, Riyadh 11461, Kingdom of Saudi Arabia.
Saudi Med J. 2012 Apr;33(4):423-8.
To investigate the presenting features of childhood-onset inflammatory bowel disease (IBD) in the central region of Riyadh, Saudi Arabia and to compare with those reported in the literature.
This is a retrospective review of medical records of children below 18 years of age at onset of symptoms with confirmed diagnosis of IBD for age, gender, family history, presenting clinical and laboratory findings in the Divisions of Pediatric and Adult Gastroenterology, King Khalid University Hospital (which provides free health care) and the Department of Gastroenterology Al Mofarreh Poly Clinic, Riyadh, Saudi Arabia, between January 1993 and December 2010.
Two hundred and eighteen children diagnosed with IBD with predominance of males in Crohn's disease (CD) (56%) and females in ulcerative colitis (UC) (59%). There was no significant difference between UC and CD regarding age of onset of symptoms (p=0.347); however, the difference in the age at presentation and age at final diagnosis were significant (p=0.027 and p=0.008). There was a significant increase of IBD diagnosis from the period 1993-2001 to 2002-2010 (p<0.0001). The family history was positive in 15.3%.
The presenting clinical features and laboratory abnormalities are similar to those reported in other populations. Further studies are needed to establish the incidence and prevalence.
调查沙特阿拉伯利雅得中部地区儿童期起病的炎症性肠病（IBD）的呈现特征，并与文献报道的特征进行比较。
这是一项对1993年1月至2010年12月期间在沙特阿拉伯利雅得的哈立德国王大学医院（提供免费医疗服务）儿科和成人胃肠病科以及Al Mofarreh综合诊所胃肠病科确诊为IBD的18岁以下有症状儿童的病历进行的回顾性研究，研究内容包括年龄、性别、家族史、呈现的临床和实验室检查结果。
218名被诊断为IBD的儿童，克罗恩病（CD）中男性占优势（56%），溃疡性结肠炎（UC）中女性占优势（59%）。UC和CD在症状出现年龄方面无显著差异（p = 0.347）；然而，就诊年龄和最终诊断年龄的差异具有显著性（p = 0.027和p = 0.008）。1993 - 2001年至2002 - 2010年期间IBD诊断有显著增加（p < 0.0001）。家族史阳性率为15.3%。
呈现的临床特征和实验室异常与其他人群报道的相似。需要进一步研究以确定发病率和患病率。
