蜂胶苯并呋喃B的全合成
Total Synthesis of Propolisbenzofuran B.
作者信息
Jones Brian T, Avetta Christopher T, Thomson Regan J
机构信息
Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208 USA.
出版信息
Chem Sci. 2014 May 1;5(5):1794-1798. doi: 10.1039/C4SC00356J.
Abstract
The first total synthesis of propolisbenzofuran B, a bioactive natural product isolated from honeybee propolis resin, is reported. The convergent synthesis makes use of a silicon-tether controlled oxidative ketone-ketone cross-coupling and a novel benzofuran-generating cascade reaction to deliver the core structure of the natural product from readily prepared precursors.
摘要
据报道，首次全合成了从蜜蜂蜂胶树脂中分离出的具有生物活性的天然产物蜂胶苯并呋喃B。该汇聚式合成利用了硅连接体控制的氧化酮-酮交叉偶联反应和一种新型的苯并呋喃生成串联反应，从易于制备的前体出发构建出该天然产物的核心结构。
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