女童未治疗的无症状菌尿症：I——尿液分离菌的稳定性
Untreated asymptomatic bacteriuria in girls: I--Stability of urinary isolates.
作者信息
Hansson S, Caugant D, Jodal U, Svanborg-Edén C
机构信息
Department of Paediatrics, Gothenburg University, East Hospital, Sweden.
出版信息
BMJ. 1989 Apr 1;298(6677):853-5. doi: 10.1136/bmj.298.6677.853.
Abstract
OBJECTIVE
To assess the frequency of spontaneous changes of bacterial strains in patients with untreated asymptomatic bacteriuria.
DESIGN
Retrospective analysis of samples from all patients with renal scarring and random sample of patients with normal kidneys.
SETTING
Outpatient clinic for children with urinary tract infections.
PATIENTS
54 Girls aged 3.3-15.5 years with untreated asymptomatic bacteriuria caused by Escherichia coli.
INTERVENTION
None.
END POINT
Change in bacterial strain.
MEASUREMENTS AND RESULTS
Serotyping and electrophoretic analysis of sequential bacterial isolates, representing 151 patient years of untreated asymptomatic bacteriuria. A total of 24 changes of strain were identified. Eleven were related to medical interference such as treatment of other infections with antibiotics.
CONCLUSIONS
Spontaneous changes of strain were uncommon, one change in 11.6 patient years, and thus are not a characteristic feature of the course of asymptomatic bacteriuria.
摘要
目的
评估未经治疗的无症状菌尿症患者中细菌菌株自发变化的频率。
设计
对所有有肾瘢痕的患者样本以及肾脏正常患者的随机样本进行回顾性分析。
地点
儿童尿路感染门诊。
患者
54名年龄在3.3至15.5岁之间的女孩，患有由大肠杆菌引起的未经治疗的无症状菌尿症。
干预措施
无。
终点指标
细菌菌株的变化。
测量与结果
对连续的细菌分离株进行血清分型和电泳分析，代表151个患者年的未经治疗的无症状菌尿症。共鉴定出24株菌株变化。其中11株与医疗干预有关，如用抗生素治疗其他感染。
结论
菌株的自发变化并不常见，每11.6个患者年出现1次变化，因此不是无症状菌尿症病程的特征性表现。
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