Wang Jianting, Coburn James, Liang Chia-Pin, Woolsey Nicholas, Ramella-Roman Jessica C, Chen Yu, Pfefer T Joshua
Opt Lett. 2014 May 15;39(10):3010-3. doi: 10.1364/OL.39.003010.
We have investigated the potential of tissue phantoms fabricated with thermosoftening- and photopolymerization-based three-dimensional (3D) printers for use in evaluation of biophotonic imaging systems. The optical properties of printed polymer samples were measured and compared to biological tissues. Phantoms with subsurface channels as small as 0.2 mm in diameter were fabricated and imaged with microscopy, x-ray microtomography, and optical coherence tomography to characterize morphology. These phantoms were then implemented to evaluate the penetration depth of a hyperspectral reflectance imaging system used in conjunction with a near-infrared contrast agent. Results indicated that 3D printing may provide a suitable platform for performance testing in biophotonics, although subsurface imaging is critical to mitigate printer-to-printer variability in matrix homogeneity and feature microstructure.
我们研究了使用基于热软化和光聚合的三维（3D）打印机制造的组织模型在生物光子成像系统评估中的潜力。测量了打印聚合物样品的光学特性，并与生物组织进行了比较。制造了直径小至0.2毫米的具有地下通道的模型，并通过显微镜、X射线显微断层扫描和光学相干断层扫描对其进行成像，以表征其形态。然后使用这些模型评估与近红外造影剂联合使用的高光谱反射成像系统的穿透深度。结果表明，3D打印可为生物光子学中的性能测试提供合适的平台，尽管地下成像对于减轻打印机之间在基质均匀性和特征微观结构方面的差异至关重要。
