Mille Matthew M, Griffin Keith T, Maass-Moreno Roberto, Lee Choonsik
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Department of Nuclear Medicine, National Institutes of Health, Bethesda, MD, USA.
J Appl Clin Med Phys. 2020 Nov;21(11):226-236. doi: 10.1002/acm2.13064. Epub 2020 Oct 19.
To demonstrate an on-demand and nearly automatic method for fabricating tissue-equivalent physical anthropomorphic phantoms for imaging and dosimetry applications using a dual nozzle thermoplastic three-dimensional (3D) printer and two types of plastic.
Two 3D printing plastics were investigated: (a) Normal polylactic acid (PLA) as a soft tissue simulant and (b) Iron PLA (PLA-Fe), a composite of PLA and iron powder, as a bone simulant. The plastics and geometry of a 1-yr-old computational phantom were combined with a dual extrusion 3D printer to fabricate an anthropomorphic imaging phantom. The volumetric fill density of the 3D-printed parts was varied to approximate tissues of different radiographic density using a calibration curve relating the printer infill density setting to measured CT number. As a demonstration of our method we printed a 10 cm axial cross-section of the computational phantom's torso at full scale. We imaged the phantom on a CT scanner and compared HU values to those of a 1-yr-old patient and a commercial 5-yr-old physical phantom.
The phantom was printed in six parts over the course of a week. The printed phantom included 30 separate anatomical regions including soft tissue remainder, lungs (left and right), heart, esophagus, rib cage (left and right ribs 1 to 10), clavicles (left and right), scapulae (left and right), thoracic vertebrae (one solid object defining thoracic vertebrae T1 to T9). CT scanning of the phantom showed five distinct radiographic regions (heart, lung, soft tissue remainder, bone, and air cavity) despite using only two types of plastic. The 3D-printed phantom demonstrated excellent similarity to commercially available phantoms, although key limitations in the printer and printing materials leave opportunity for improvement.
Patient-specific anthropomorphic phantoms can be 3D printed and assembled in sections for imaging and dosimetry applications. Such phantoms will be useful for dose verification purposes when commercial phantoms are unavailable for purchase in the specific anatomies of interest.
展示一种按需且近乎自动的方法,该方法使用双喷嘴热塑性三维(3D)打印机和两种类型的塑料来制造用于成像和剂量测定应用的组织等效物理拟人化体模。
研究了两种3D打印塑料:(a)普通聚乳酸(PLA)作为软组织模拟物,以及(b)铁聚乳酸(PLA-Fe),一种PLA与铁粉的复合材料,作为骨模拟物。将一岁计算体模的塑料和几何形状与双挤出3D打印机相结合,以制造拟人化成像体模。利用将打印机填充密度设置与测量的CT值相关联的校准曲线,改变3D打印部件的体积填充密度,以近似不同射线密度的组织。作为我们方法的一个示范,我们按全尺寸打印了计算体模躯干的10厘米轴向横截面。我们在CT扫描仪上对该体模进行成像,并将HU值与一名一岁患者和一个商用五岁物理体模的HU值进行比较。
该体模在一周内分六个部分打印完成。打印的体模包括30个独立的解剖区域,包括软组织剩余部分、肺(左和右)、心脏、食管、肋骨笼(左和右肋骨1至10)、锁骨(左和右)、肩胛骨(左和右)、胸椎(一个定义胸椎T1至T9的实心物体)。尽管仅使用了两种类型的塑料,但对该体模的CT扫描显示出五个不同的射线区域(心脏、肺、软组织剩余部分、骨骼和气腔)。尽管打印机和打印材料存在关键限制,但3D打印体模与商用体模显示出极佳的相似性,仍有改进空间。
特定患者的拟人化体模可以通过3D打印并分段组装,用于成像和剂量测定应用。当在感兴趣的特定解剖结构中无法购买到商用体模时,此类体模将有助于剂量验证。