Burgos David, Blumenkopf Bennett, Afshari Ali, Snodderly Kirstie, Pfefer T Joshua
Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, Maryland, United States.
Neurophotonics. 2023 Jan;10(1):015007. doi: 10.1117/1.NPh.10.1.015007. Epub 2023 Mar 15.
Neurosurgical fluorescence imaging is a well-established clinical approach with a growing range of indications for use. However, this technology lacks effective phantom-based tools for development, performance testing, and clinician training.
Our primary aim was to develop and evaluate 3D-printed phantoms capable of optically and morphologically simulating neurovasculature under fluorescence angiography.
Volumetric digital maps of the circle of Willis with basilar and posterior communicator artery aneurysms, along with surrounding cerebral tissue, were generated. Phantoms were fabricated with a stereolithography printer using custom photopolymer composites, then visualized under white light and near-infrared fluorescence imaging.
Feature sizes of printed components were found to be within 13% of digital models. Phantoms exhibited realistic optical properties and convincingly recapitulated fluorescence angiography scenes.
Methods identified in this study can facilitate the development of realistic phantoms as powerful new tools for fluorescence imaging.
神经外科荧光成像技术是一种成熟的临床方法，其应用范围不断扩大。然而，这项技术缺乏用于开发、性能测试和临床医生培训的有效模型工具。
我们的主要目的是开发和评估能够在荧光血管造影下光学和形态学模拟神经血管系统的3D打印模型。
生成了包含基底动脉和后交通动脉瘤的Willis环以及周围脑组织的体积数字地图。使用定制的光聚合物复合材料通过立体光刻打印机制造模型，然后在白光和近红外荧光成像下进行可视化。
发现打印部件的特征尺寸在数字模型的13%以内。模型具有逼真的光学特性，并令人信服地重现了荧光血管造影场景。
本研究中确定的方法可以促进逼真模型的开发，作为荧光成像的强大新工具。
