Dehamchia-Rehailia N, Ursu D, Henry-Desailly I, Fardellone P, Paccou J
Department of Rheumatology, Amiens University Hospital, 80054, Amiens, France.
Osteoporos Int. 2014 Oct;25(10):2409-16. doi: 10.1007/s00198-014-2774-6. Epub 2014 Jul 1.
The main goal was to assess the performance of the fracture liaison service (FLS) at Amiens University Hospital for 2 years. Osteoporosis medication was prescribed in 182 patients and 67.4 % were still taking treatment 18 months later. Secondary prevention of osteoporotic fractures has improved since the creation of the FLS.
The main goal of the present study was to assess the performance and results of the FLS at Amiens University Hospital, France.
This was an observational, single-center, ambispective study. All patients admitted to Amiens University Hospital between January 2010 and December 2011 for a low-trauma fracture (vertebral and non-vertebral fractures) were identified by a FLS nurse. Patients willing to enter the study were assessed for their osteoporosis risk factors, daily calcium intake, bone mineral density (BMD) by DXA, and clinical chemistry parameters. When indicated, the patients received a prescription for osteoporosis medication. The participation rate, type of osteoporosis medications, initiation rate, and osteoporosis treatment persistence 12 and 18 months later were assessed.
Of the 1,439 patients contacted, 872 were eligible for inclusion. A total of 335 patients (participation rate 38.4 %) were included in the study (mean age 63.3 years; 71.9 % female). All patients underwent BMD measurement, and more than 90 % of them were assessed for osteoporosis risk factors and daily calcium intake. Osteoporosis medication was prescribed in 182 (75.5 %) of the patients in whom it was indicated (n = 241). The main class of osteoporosis medications prescribed was bisphosphonates (83.5 %), and 74.1 and 67.4 % of treated patients were still taking treatment 12 and 18 months later, respectively. The main cause of treatment discontinuation was non-renewal of the prescription by the patient's general practitioner.
Secondary prevention of osteoporotic fractures in Amiens University Hospital has improved since the creation of the FLS, with encouragingly high treatment initiation and persistence rates.
主要目标是评估亚眠大学医院骨折联络服务（FLS）两年的表现。182例患者开具了骨质疏松症药物处方，18个月后仍有67.4%的患者继续接受治疗。自FLS设立以来，骨质疏松性骨折的二级预防有所改善。
本研究的主要目标是评估法国亚眠大学医院FLS的表现和结果。
这是一项观察性、单中心、前后瞻性研究。2010年1月至2011年12月期间因低创伤骨折（椎体和非椎体骨折）入住亚眠大学医院的所有患者均由FLS护士识别。愿意参加研究的患者接受骨质疏松症风险因素、每日钙摄入量、通过双能X线吸收法（DXA）测量的骨密度（BMD）以及临床化学参数的评估。如有需要，患者会收到骨质疏松症药物处方。评估参与率、骨质疏松症药物类型、起始率以及12个月和18个月后的骨质疏松症治疗持续率。
在1439名被联系的患者中，872名符合纳入条件。共有335名患者（参与率38.4%）被纳入研究（平均年龄63.3岁；71.9%为女性）。所有患者均进行了BMD测量，超过90%的患者接受了骨质疏松症风险因素和每日钙摄入量评估。在241名有指征的患者中，182名（75.5%）开具了骨质疏松症药物处方。所开具的主要骨质疏松症药物类别为双膦酸盐（83.5%），12个月和18个月后仍在接受治疗的患者分别为74.1%和67.4%。治疗中断的主要原因是患者的全科医生未续签处方。
自FLS设立以来，亚眠大学医院骨质疏松性骨折的二级预防有所改善，治疗起始率和持续率高，令人鼓舞。
