Haldón Estela, Álvarez Eleuterio, Nicasio M Carmen, Pérez Pedro J
Laboratorio de Catálisis Homogénea, Unidad Asociada al CSIC, CIQSO-Centro de Investigación en Química Sostenible and Departamento de Química y Ciencias de los Materiales, Campus de El Carmen s/n, Universidad de Huelva, 21007-Huelva, Spain.
Chem Commun (Camb). 2014 Aug 18;50(64):8978-81. doi: 10.1039/c4cc03614j.
Electron deficient azides are challenging substrates in CuAAC reactions. Particularly, when N-carbonyl azides are applied the formation of N-carbonyl triazoles has not yet been observed. We report herein the first example of this class of reaction, with a copper-based system that efficiently enables the synthesis of N-carbamoyl 1,2,3-triazoles by [3+2] cycloaddition of N-carbamoyl azides and alkynes.
缺电子叠氮化物在铜催化的叠氮化物-炔烃环加成（CuAAC）反应中是具有挑战性的底物。特别是，当使用N-羰基叠氮化物时，尚未观察到N-羰基三唑的形成。我们在此报告了这类反应的首个实例，即使用基于铜的体系，通过N-氨基甲酰基叠氮化物与炔烃的[3+2]环加成反应，高效合成N-氨基甲酰基-1,2,3-三唑。
