血液中的2,5-二甲基呋喃作为吸烟的一种敏感且特异的生物标志物。
Blood 2,5-dimethylfuran as a sensitive and specific biomarker for cigarette smoking.
作者信息
Jia Chunrong, Ward Kenneth D, Mzayek Fawaz, Relyea George
机构信息
School of Public Health, University of Memphis , Memphis, TN , USA.
出版信息
Biomarkers. 2014 Sep;19(6):457-62. doi: 10.3109/1354750X.2014.935956. Epub 2014 Jul 1.
OBJECTIVE
We evaluated the validity of blood 2,5-dimethylfuran (DMF) for determining smoking status using population-based data.
METHODS
We obtained blood DMF concentrations and smoking status from National Health and Nutrition Examination Survey 2003-2006 and computed sensitivity, specificity and Kappa statistic.
RESULTS
Self-reported smoking showed very high agreement (Kappa = 92.8-93.3%) in daily smokers and fair agreement in non-daily smokers (Kappa = 33.7-36.4%). Coffee intake did not influence the detection of blood DMF.
CONCLUSIONS
Blood DMF has comparable sensitivity and specificity with serum cotinine for identifying current daily smokers, which may make it a useful biomarker in epidemiologic studies.
目的
我们利用基于人群的数据评估了血液中2,5 - 二甲基呋喃（DMF）用于确定吸烟状况的有效性。
方法
我们从2003 - 2006年国家健康与营养检查调查中获取了血液DMF浓度和吸烟状况，并计算了敏感性、特异性和kappa统计量。
结果
自我报告的吸烟情况在每日吸烟者中显示出非常高的一致性（kappa = 92.8 - 93.3%），在非每日吸烟者中一致性一般（kappa = 33.7 - 36.4%）。咖啡摄入量不影响血液DMF的检测。
结论
血液DMF在识别当前每日吸烟者方面具有与血清可替宁相当的敏感性和特异性，这可能使其成为流行病学研究中的一种有用生物标志物。
Zotero 插件