Korsch Michael, Walther Winfried, Marten Silke-Mareike, Obst Ursula
1 Dental Academy for Continuing Professional Development, Karlsruhe - Germany.
J Appl Biomater Funct Mater. 2014 Sep 5;12(2):70-80. doi: 10.5301/jabfm.5000206.
The cementation of implant-supported restorations always poses the risk of excess cement retained in the peri-implant sulcus despite careful clinical control. Excess cement can become the basis of colonization by oral microorganisms. As a result of the biofilm formation peri-mucositis or peri-implantitis may develop. Complications were observed in the routine prosthetic restoration of implants when a methacrylate-based cement was used. These developed a few weeks after cementation of the suprastructure and caused bleeding on probing as well as suppuration from the peri-implant tissue. In the revision therapy, excess cement in the peri-implant sulcus was found in many cases. This excess cement was sampled from ten patients and investigated for biofilm formation. For this purpose, the cement samples were collected and analyzed for bacterial in situ colonization by 16S rDNA-based methods. In laboratory experiments, the methacrylate-based cement and two other dental cements were then investigated for their proneness to form biofilm. The results of the in situ and in vitro investigations revealed a strong tendency towards bacterial invasion of the methacrylate-based cement by opportunistic species and pathogens.
尽管有仔细的临床控制，但种植体支持修复体的黏固总是存在种植体周围龈沟内残留过多黏固剂的风险。过多的黏固剂会成为口腔微生物定植的基础。由于生物膜形成，可能会发展为种植体周围黏膜炎或种植体周围炎。在使用甲基丙烯酸酯类黏固剂进行种植体常规修复时观察到了并发症。这些并发症在上部结构黏固几周后出现，导致探诊出血以及种植体周围组织化脓。在翻修治疗中，许多病例在种植体周围龈沟发现了过多的黏固剂。从10名患者中采集了这些过多的黏固剂样本，并对其生物膜形成情况进行了研究。为此，收集黏固剂样本，并通过基于16S rDNA的方法分析细菌原位定植情况。在实验室实验中，随后研究了甲基丙烯酸酯类黏固剂和其他两种牙科黏固剂形成生物膜的倾向。原位和体外研究结果显示，机会性菌种和病原菌对甲基丙烯酸酯类黏固剂有很强的细菌侵入倾向。
