College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA.
Vet Clin North Am Food Anim Pract. 2014 Jul;30(2):295-316, v. doi: 10.1016/j.cvfa.2014.03.001. Epub 2014 May 28.
The Henderson-Hasselbalch equation is probably the most famous equation in biology but is more descriptive than mechanistic. The traditional approach to acid-base assessment using the Henderson-Hasselbalch equation provides a clinically useful and accurate method when plasma protein concentrations are within the reference range. The simplified strong ion approach is a mechanistic acid-base model that can provide new insight into complicated acid-base disturbances. The simplified strong ion approach should be used to evaluate acid-base balance whenever plasma protein concentrations are abnormal.
亨德森-哈塞尔巴尔赫方程可能是生物学中最著名的方程，但它更具描述性而非机械性。当血浆蛋白浓度在参考范围内时，使用亨德森-哈塞尔巴尔赫方程进行酸碱评估的传统方法提供了一种临床有用且准确的方法。简化的强离子方法是一种机械酸碱模型，可以为复杂的酸碱紊乱提供新的见解。只要血浆蛋白浓度异常，就应该使用简化的强离子方法来评估酸碱平衡。
