Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom.
Department of Biology, University of York, York, United Kingdom
Infect Immun. 2014 Sep;82(9):3811-5. doi: 10.1128/IAI.02025-14. Epub 2014 Jun 30.
Nasal carriage of Staphylococcus aureus is a risk factor for infection, yet the bacterial determinants required for carriage are poorly defined. Interactions between S. aureus and other members of the bacterial flora may determine colonization and have been inferred in previous studies by using correlated species distributions. However, traits mediating species interactions are often polymorphic, suggesting that understanding how interactions structure communities requires a trait-based approach. We characterized S. aureus growth inhibition by the culturable bacterial aerobe consortia of 60 nasal microbiomes, and this revealed intraspecific variation in growth inhibition and that inhibitory isolates clustered within communities that were culture negative for S. aureus. Across microbiomes, the cumulative community-level growth inhibition was negatively associated with S. aureus incidence. To fully understand the ecological processes structuring microbiomes, it will be crucial to account for intraspecific variation in the traits that mediate species interactions.
金黄色葡萄球菌（Staphylococcus aureus）的鼻腔携带是感染的一个风险因素，但对于携带所需的细菌决定因素还了解甚少。金黄色葡萄球菌与其他细菌菌群成员之间的相互作用可能决定了定植，并且在之前的研究中已经通过相关物种分布进行了推断。然而，介导物种相互作用的特征通常是多态的，这表明要理解相互作用如何构建群落，需要采用基于特征的方法。我们通过 60 个鼻腔微生物组中可培养需氧细菌共生体的特征来描述金黄色葡萄球菌的生长抑制作用，这揭示了生长抑制的种内变异，并且具有抑制作用的分离株聚集在金黄色葡萄球菌培养阴性的群落中。在整个微生物组中，累积的群落水平生长抑制与金黄色葡萄球菌的发病率呈负相关。为了充分理解构建微生物组的生态过程，至关重要的是要考虑介导物种相互作用的特征的种内变异。
