Hung T T, Ribas D, Tsuiki A, Preyer J, Slackman R, Davidson O W
University of Miami School of Medicine, Department of Obstetrics and Gynecology, Florida 33101.
Fertil Steril. 1989 Jun;51(6):968-71.
In order to study the feasibility and efficacy of using natural 17 beta-estradiol (E2) and progesterone (P) to induce endometrial changes, a group of patients with history of premature ovarian failure and bilateral oophorectomy, also interested in the embryo transfer program with donor ovum, were given transdermal E2 (Estraderm, Ciba Pharmaceutical Co., Summit, NJ), and vaginal progesterone suppositories. Serial serum E2, P, follicle-stimulating hormone, and luteinizing hormone were determined by radioimmunoassays. The dosages of E2 and P were adjusted according to the levels of E2 and P so that their changes could follow the same pattern as that of a normal spontaneous menstrual cycle. Serial ultrasonic evaluation of the endometrium and endometrial biopsy during the late luteal phase also was performed. Preliminary data indicated that transdermal E2 patches and vaginal P suppositories, while being as effective in inducing endometrial development for the embryo transfer procedure with donor ovum as synthetic steroids, can also provide a more physiologic approach that may conveniently and safely be extended into the second trimester of pregnancy.
为研究使用天然17β-雌二醇（E2）和孕酮（P）诱导子宫内膜变化的可行性和疗效，选取了一组有卵巢早衰病史且双侧卵巢已切除的患者，她们也有意参与供卵胚胎移植计划，给予她们经皮E2（雌二醇透皮贴剂，汽巴制药公司，新泽西州萨米特）和阴道孕酮栓剂。通过放射免疫分析法测定血清E2、P、促卵泡激素和促黄体生成素的系列水平。根据E2和P的水平调整E2和P的剂量，使其变化能遵循与正常自发月经周期相同的模式。同时在黄体晚期对子宫内膜进行系列超声评估及子宫内膜活检。初步数据表明，经皮E2贴片和阴道P栓剂在诱导子宫内膜发育以用于供卵胚胎移植程序方面与合成类固醇同样有效，还能提供一种更符合生理的方法，可方便且安全地延续至妊娠中期。
