低血清胃蛋白酶原水平对检测日本人群中与广泛慢性胃炎相关的胃癌的意义。
The significance of low serum pepsinogen levels to detect stomach cancer associated with extensive chronic gastritis in Japanese subjects.
作者信息
Miki K, Ichinose M, Kawamura N, Matsushima M, Ahmad H B, Kimura M, Sano J, Tashiro T, Kakei N, Oka H
机构信息
First Department of Internal Medicine, Faculty of Medicine, University of Tokyo.
出版信息
Jpn J Cancer Res. 1989 Feb;80(2):111-4. doi: 10.1111/j.1349-7006.1989.tb02276.x.
Abstract
Serum pepsinogen levels were measured in 137 stomach cancer patients and compared with those of 288 normal cancer-free subjects. The serum pepsinogen levels of stomach cancer patients, especially pepsinogen I and the pepsinogen I/pepsinogen II ratio were significantly lower than those of normal controls and correlated well with the extent of chronic gastritis associated with the cancerous stomach. These results were in good accordance with the results of previous studies indicating that the cancer derived from the stomach where chronic gastritis/intestinal metaplasia is extensive. The high sensitivity and specificity of this non-invasive serum test to detect chronic gastritis suggested the possibility of its application to the mass screening of stomach cancer.
摘要
对137例胃癌患者的血清胃蛋白酶原水平进行了检测，并与288例无癌正常受试者的水平进行了比较。胃癌患者的血清胃蛋白酶原水平，尤其是胃蛋白酶原I和胃蛋白酶原I/胃蛋白酶原II比值，显著低于正常对照组，且与癌胃相关的慢性胃炎程度密切相关。这些结果与先前的研究结果高度一致，先前的研究表明癌症起源于慢性胃炎/肠化生广泛的胃部。这种检测慢性胃炎的非侵入性血清检测具有高灵敏度和特异性，提示了其应用于胃癌大规模筛查的可能性。
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