Chen R H, Buko A M, Whittern D N, McAlpine J B
Anti-infective Research, Abbott Laboratories, Abbott Park, Illinois 60064.
J Antibiot (Tokyo). 1989 Apr;42(4):512-20. doi: 10.7164/antibiotics.42.512.
A novel class of antibiotics was isolated from cultures of Streptomyces coeruleorubidus strain AB 1183F-64. The antimicrobial activity of the pacidamycins is selective against Pseudomonas aeruginosa. The various congeners are nucleoside peptides which differ in the terminal amino acid residues. The structures were determined using MS-MS and 2D NMR techniques.
从天蓝红链霉菌菌株AB 1183F-64的培养物中分离出一类新型抗生素。帕西达霉素的抗菌活性对铜绿假单胞菌具有选择性。各种同系物是在末端氨基酸残基上有所不同的核苷肽。其结构通过串联质谱法和二维核磁共振技术确定。
