Isono F, Inukai M, Takahashi S, Haneishi T, Kinoshita T, Kuwano H
Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
J Antibiot (Tokyo). 1989 May;42(5):667-73. doi: 10.7164/antibiotics.42.667.
Structures of new antibiotics, mureidomycins (MRD's) A approximately D, were deduced from spectroscopic analyses and degradation studies. Two residues of m-tyrosine, one residue of 2-amino-3-N-methylaminobutyric acid (AMBA) and methionine are present in all components of the complex. Uracil is contained in MRD's A and C, while dihydrouracil in MRD's B and D. Methionine and m-tyrosine are connected through an ureido bond, and uracil or dihydrouracil is linked to AMBA via enamine sugar moiety. In addition, MRD's C and D contain a glycine residue at the N-terminal.
新型抗生素穆雷霉素（MRD's）A至D的结构是通过光谱分析和降解研究推导出来的。该复合物的所有组分中均存在两个间酪氨酸残基、一个2-氨基-3-N-甲基氨基丁酸（AMBA）残基和甲硫氨酸。MRD's A和C含有尿嘧啶，而MRD's B和D含有二氢尿嘧啶。甲硫氨酸和间酪氨酸通过脲基键相连，尿嘧啶或二氢尿嘧啶通过烯胺糖部分与AMBA相连。此外，MRD's C和D在N端含有一个甘氨酸残基。
