Central Diagnostic Laboratory, Maastricht University Medical Centre, Maastricht, The Netherlands.
Clin Exp Rheumatol. 2014 Jul-Aug;32(4):539-46. Epub 2014 Jun 30.
One of the main goals of the European Autoimmunity Standardisation Initiative (EASI) is the harmonisation of test-algorithms for autoantibodies related to systemic autoimmune rheumatic diseases (SARD).
A questionnaire was used to gather information on methodology, interpretation, and the algorithm for detection of anti-nuclear antibodies (ANA) in relation to their antigen-specificity. The questionnaire was sent to 1200 laboratories in 12 European countries.
The response rate was 47.2%. The results reveal not only apparent differences between countries, but also within countries.
Awareness of these differences may as such already stimulate harmonisation, but the observed differences may also direct recommendations that may further contribute to achieving the EASI goal of harmonisation of autoimmune diagnostics for SARD.
欧洲自身免疫标准化倡议 (EASI) 的主要目标之一是协调与系统性自身免疫性风湿病 (SARD) 相关的自身抗体检测算法。
使用问卷收集有关核抗体 (ANA) 检测方法、解释和算法的信息，以及它们的抗原特异性。该问卷发送给了 12 个欧洲国家的 1200 个实验室。
回复率为 47.2%。结果不仅显示了国家之间的明显差异，也显示了国家内部的差异。
对这些差异的认识本身可能会促进协调，但观察到的差异也可能为进一步实现 EASI 协调 SARD 自身免疫诊断的目标提供建议。
