Zhang Lizhi, Li Zejiang, Liu Zhong-Quan
State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou Gansu 730000, P. R. China.
Org Lett. 2014 Jul 18;16(14):3688-91. doi: 10.1021/ol5014747. Epub 2014 Jul 1.
An I(2)O(5)-promoted free-radical cascade trifluoromethylation/cyclization of a broad range of N-arylmethacrylamides and enynes with sodium trifluoromethanesulfinate in aqueous medium has been achieved. This strategy allows highly selective access to a variety of CF(3)-containing oxindoles and pyrrolidines. Electron spin resonance (ESR) studies indicate that atom-transfer processes are involved in this system.
已实现了在水介质中，I(2)O(5)促进的一系列N-芳基甲基丙烯酰胺和烯炔与三氟甲磺酸钠的自由基级联三氟甲基化/环化反应。该策略能够高度选择性地合成多种含CF(3)的氧化吲哚和吡咯烷。电子自旋共振（ESR）研究表明该体系涉及原子转移过程。
