Aghaei Maryam, Aghaei Shahrzad, Behshadnia Fatemeh, Ghomashlooyan Mohsen, Khaghani Armin, Baradaran Elahe H, Naeini Farahnaz F, Iraji Fariba, Shahmoradi Zabihollah, Hosseini Sayed M, Hejazi Seyed H
Skin Diseases and Leishmaniasis Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Molecular Medicine, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Adv Biomed Res. 2023 Jun 30;12:173. doi: 10.4103/abr.abr_236_22. eCollection 2023.
Rosacea is a multifactorial skin inflammatory disorder with an unknown cure. Genetics and environmental factors such as microorganisms are involved in the rosacea etiology, for example, have been suggested in rosacea progression. The present study investigated the relationship between eradication and rosacea patient's improvement.
infection was investigated in 60 rosacea patients and 65 sex- and age-matched healthy control through enzyme-linked immunosorbent assay (ELISA) and HpSag tests. After infection confirmation, randomly half of the rosacea patients were treated for eradication (test), and others received standard treatment (control). HpSag and ELISA tests were repeated after infection eradication and disease flow was surveyed for 60 days. The groups were compared using the ANOVA (Analysis Of Variance) test at the significant level of < 0.05.
At the baseline, the mean of immunoglobulin G (IgG) (59.27 ± 41.4 RU/mL) and immunoglobulin M (IgM) (11.55 ± 6.1 RU/mL) in rosacea patients was higher than the level of IgG (41.38 ± 54.33 RU/mL) and IgM (8.11 ± 8.91 RU/mL) in healthy control ( < 0.04) and ( < 0.01), respectively. Also, the values for infection were positive in all patients and 10 healthy controls. The mean titer of IgM and IgG in the test and control patients groups were different at baseline and after treatment. Furthermore, in the test patients group, the mean of IgG was reduced in active rosacea after treatment, and 63.9% of active patients showed rosacea remission after eradication.
Data suggest the exacerbating role of in rosacea, and its eradication along with other therapeutic methods causes rosacea improvement.
酒渣鼻是一种多因素引起的皮肤炎症性疾病，目前尚无治愈方法。遗传学和微生物等环境因素参与了酒渣鼻的病因，例如，已被认为与酒渣鼻的进展有关。本研究调查了根除[某种微生物]与酒渣鼻患者病情改善之间的关系。
通过酶联免疫吸附测定（ELISA）和[某种微生物]特异性抗原（HpSag）检测，对60例酒渣鼻患者和65例年龄及性别匹配的健康对照者进行[某种微生物]感染调查。在确认感染后，随机将一半的酒渣鼻患者进行[某种微生物]根除治疗（试验组），其余患者接受标准治疗（对照组）。在根除感染后重复进行HpSag和ELISA检测，并对疾病进展情况进行60天的监测。使用方差分析（ANOVA）检验对两组进行比较，显著性水平设定为P<0.05。
在基线时，酒渣鼻患者的免疫球蛋白G（IgG）（59.27±41.4 RU/mL）和免疫球蛋白M（IgM）（11.55±6.1 RU/mL）平均值高于健康对照者的IgG（41.38±54.33 RU/mL）和IgM（8.11±8.91 RU/mL）水平，P值分别<0.04和<0.01。此外，所有患者和10名健康对照者的[某种微生物]感染检测结果均为阳性。试验组和对照组患者在基线和治疗后的IgM和IgG平均滴度不同。此外，在试验组患者中，治疗后活动性酒渣鼻患者的IgG平均值降低，63.9%的活动性患者在根除[某种微生物]后酒渣鼻症状缓解。
数据表明[某种微生物]在酒渣鼻中起加重作用，根除该微生物并结合其他治疗方法可使酒渣鼻病情改善。
