Høvik P, Sundsbak H P, Gaasemyr M, Sandvik L
Maturitas. 1989 Mar;11(1):75-82. doi: 10.1016/0378-5122(89)90122-9.
Continuous (Kliogest) and sequential (Trisequens) oestrogen-progestogen treatment were compared in a randomized, parallel, group study in women suffering from climacteric symptoms. The subjects were treated with Trisequens for 4 mth prior to randomized assignment to 1 of 2 treatment groups, and with either Trisequens or Kliogest for 12 mth thereafter. Forty-one (41) patients were initially recruited for the study. Of these, 34 completed the study, each treatment group hence comprised 17 women. The results suggest that continuous treatment is as effective as sequential treatment in alleviating climacteric symptoms. Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels were significantly reduced after changeover from sequential to continuous treatment (LH: P less than 0.001; FSH: P less than 0.01). Breast cancer was detected in 2 women, 1 being from each treatment group. Weight, blood pressure and cholesterol concentrations were not significantly altered in either of the groups. There were no cases of endometrial hyperplasia. In the continuous-treatment group a temporary increase in breakthrough bleeding occurred at the beginning of the treatment period. It was concluded that continuous treatment seems to constitute an efficacious regimen for climacteric symptoms, which does not induce monthly bleeding.
在一项针对患有更年期症状女性的随机、平行分组研究中，对连续服用（Kliogest）和序贯服用（Trisequens）雌激素 - 孕激素治疗进行了比较。在随机分配至2个治疗组之一之前，受试者先服用Trisequens 4个月，之后再服用Trisequens或Kliogest 12个月。最初招募了41名患者参与该研究。其中，34名完成了研究，每个治疗组因此包含17名女性。结果表明，连续治疗在缓解更年期症状方面与序贯治疗同样有效。从序贯治疗转换为连续治疗后，促黄体生成素（LH）和促卵泡生成素（FSH）水平显著降低（LH：P < 0.001；FSH：P < 0.01）。2名女性被检测出患有乳腺癌，每个治疗组各有1例。两组的体重、血压和胆固醇浓度均无显著变化。未出现子宫内膜增生病例。在连续治疗组中，治疗初期出现了突破性出血的短暂增加。结论是，连续治疗似乎是一种治疗更年期症状的有效方案，不会引起每月出血。
