Fink B J
Maturitas. 1984 Apr;5(4):277-80. doi: 10.1016/0378-5122(84)90022-7.
Eight women with primary failure of ovarian function and twelve women undergoing the climacteric were treated sequentially with oestradiol-oestriol and norethisterone acetate (Trisequens and Trisequens Forte, Novo). After a mean treatment period of 5 yr (range 3-8 yr) endometrial biopsies were taken on day 11 or 12 at the end of an oestrogen-only phase. All biopsies showed the presence of a proliferative endometrium without any signs of hyperplasia or carcinoma in situ. Although cyclic oestrogen therapy can cause hyperplasia, a small dose of a progestogen (norethisterone acetate 1 mg) for 10 days in a 28-day cycle can prevent hyperplasia of the endometrium during long-term treatment.
八名原发性卵巢功能衰竭的女性和十二名处于更年期的女性先后接受了雌二醇-雌三醇和醋酸炔诺酮（Trisequens和Trisequens Forte，诺和诺德公司）治疗。在平均5年（范围3 - 8年）的治疗期后，在仅使用雌激素阶段结束时的第11天或第12天进行子宫内膜活检。所有活检均显示存在增殖期子宫内膜，无任何增生或原位癌迹象。尽管周期性雌激素治疗可导致增生，但在28天周期中给予小剂量孕激素（1毫克醋酸炔诺酮）10天可预防长期治疗期间子宫内膜增生。
