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表皮生长因子、胰岛素和pp60v-src对静止特异性基因表达的快速抑制

Rapid repression of quiescence-specific gene expression by epidermal growth factor, insulin, and pp60v-src.

作者信息

Bedard P A, Yannoni Y, Simmons D L, Erikson R L

机构信息

Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138.

出版信息

Mol Cell Biol. 1989 Mar;9(3):1371-5. doi: 10.1128/mcb.9.3.1371-1375.1989.

DOI:10.1128/mcb.9.3.1371-1375.1989
PMID:2498647
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC362736/
Abstract

We isolated a cDNA for p20K, a secreted protein preferentially synthesized in nonproliferating cells. p20K mRNA and protein levels declined rapidly following treatment with various mitogens. DNA sequence analysis of the p20K cDNA predicted a novel protein distantly related to alpha 2 mu-globulin and plasma retinol-binding protein.

摘要

我们分离出了p20K的互补DNA（cDNA），p20K是一种在非增殖细胞中优先合成的分泌蛋白。用各种促细胞分裂剂处理后，p20K的信使核糖核酸（mRNA）和蛋白质水平迅速下降。对p20K cDNA的DNA序列分析预测了一种与α2微球蛋白和血浆视黄醇结合蛋白有远缘关系的新蛋白质。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/163a/362736/3d84fcb24b63/molcellb00051-0507-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/163a/362736/83a52eb3eb99/molcellb00051-0506-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/163a/362736/780583ce0b9f/molcellb00051-0507-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/163a/362736/3d84fcb24b63/molcellb00051-0507-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/163a/362736/83a52eb3eb99/molcellb00051-0506-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/163a/362736/780583ce0b9f/molcellb00051-0507-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/163a/362736/3d84fcb24b63/molcellb00051-0507-b.jpg

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引用本文的文献

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Extracellular Signal-Regulated Kinase 2 and CHOP Restrict the Expression of the Growth Arrest-Specific p20K Lipocalin Gene to G0.细胞外信号调节激酶2和CHOP将生长停滞特异性p20K脂钙蛋白基因的表达限制在G0期。
Mol Cell Biol. 2016 Nov 14;36(23):2890-2902. doi: 10.1128/MCB.00338-16. Print 2016 Dec 1.
2
Ex-FABP, extracellular fatty acid binding protein, is a stress lipocalin expressed during chicken embryo development.
Mol Cell Biochem. 2002 Oct;239(1-2):221-5.
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Induction of host gene expression following infection of chicken embryo fibroblasts with oncogenic Marek's disease virus.致癌性马立克氏病病毒感染鸡胚成纤维细胞后宿主基因表达的诱导。

本文引用的文献

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Structural and functional studies of vitamin A-binding proteins.维生素A结合蛋白的结构与功能研究
Ann N Y Acad Sci. 1981 Feb 27;359:79-90. doi: 10.1111/j.1749-6632.1981.tb12739.x.
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Molecular cloning of gene sequences regulated by platelet-derived growth factor.血小板衍生生长因子调控的基因序列的分子克隆
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Sequence-specific resonance assignments of Q83, a lipocalin highly expressed in v-myc-transformed avian fibroblasts.Q83的序列特异性共振归属，Q83是一种在v-myc转化的禽成纤维细胞中高表达的脂质运载蛋白。
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C/EBPbeta (NF-M) is essential for activation of the p20K lipocalin gene in growth-arrested chicken embryo fibroblasts.C/EBPβ（NF-M）对于生长停滞的鸡胚成纤维细胞中p20K脂钙蛋白基因的激活至关重要。
Mol Cell Biol. 1999 Aug;19(8):5718-31. doi: 10.1128/MCB.19.8.5718.
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The lipocalin protein family: structure and function.脂联素蛋白家族：结构与功能。
Biochem J. 1996 Aug 15;318 ( Pt 1)(Pt 1):1-14. doi: 10.1042/bj3180001.
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Transcriptional downregulation of the retina-specific QR1 gene by pp60v-src and identification of a novel v-src-responsive unit.pp60v-src对视网膜特异性QR1基因的转录下调及一个新型v-src反应元件的鉴定。
Mol Cell Biol. 1993 Jun;13(6):3401-14. doi: 10.1128/mcb.13.6.3401-3414.1993.
8
Repression of platelet-derived growth factor beta-receptor expression by mitogenic growth factors and transforming oncogenes in murine 3T3 fibroblasts.有丝分裂原性生长因子和转化癌基因对小鼠3T3成纤维细胞中血小板衍生生长因子β受体表达的抑制作用
Mol Cell Biol. 1995 Mar;15(3):1244-53. doi: 10.1128/MCB.15.3.1244.
9
Nonsteroidal antiinflammatory drugs cause apoptosis and induce cyclooxygenases in chicken embryo fibroblasts.非甾体抗炎药可诱导鸡胚成纤维细胞凋亡并诱导环氧化酶产生。
Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7961-5. doi: 10.1073/pnas.92.17.7961.
10
Transcriptional stimulation of the retina-specific QR1 gene upon growth arrest involves a Maf-related protein.生长停滞时视网膜特异性QR1基因的转录激活涉及一种与Maf相关的蛋白。
Mol Cell Biol. 1995 Oct;15(10):5563-75. doi: 10.1128/MCB.15.10.5563.
Eur J Biochem. 1983 Jun 1;133(1):17-21. doi: 10.1111/j.1432-1033.1983.tb07424.x.
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Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.从小鼠骨髓瘤肿瘤总RNA中纯化小鼠免疫球蛋白重链信使RNA。
Eur J Biochem. 1980 Jun;107(2):303-14. doi: 10.1111/j.1432-1033.1980.tb06030.x.
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The primary structure of monomeric beta-lactoglobulin I from horse colostrum (Equus caballus, Perissodactyla).
Hoppe Seylers Z Physiol Chem. 1984 Dec;365(12):1393-401. doi: 10.1515/bchm2.1984.365.2.1393.
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Somatomedins (insulin-like growth factors), but not growth hormone, are mitogenic for chicken heart mesenchymal cells and act synergistically with epidermal growth factor and brain fibroblast growth factor.生长调节素（胰岛素样生长因子）而非生长激素，对鸡心脏间充质细胞具有促有丝分裂作用，并与表皮生长因子和脑成纤维细胞生长因子协同发挥作用。
Life Sci. 1984 Jul 23;35(4):335-46. doi: 10.1016/0024-3205(84)90643-x.
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Production of antibodies by inoculation into lymph nodes.通过接种到淋巴结中来产生抗体。
Methods Enzymol. 1983;93:3-12. doi: 10.1016/s0076-6879(83)93031-8.
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A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.一种将DNA限制性内切酶片段放射性标记至高比活度的技术。
Anal Biochem. 1983 Jul 1;132(1):6-13. doi: 10.1016/0003-2697(83)90418-9.
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Epidermal growth factor and insulin cause normal chicken heart mesenchymal cells to proliferate like their Rous sarcoma virus-infected counterparts.表皮生长因子和胰岛素会使正常鸡心脏间充质细胞像被劳氏肉瘤病毒感染的对应细胞一样增殖。
Proc Natl Acad Sci U S A. 1982 Feb;79(4):1154-7. doi: 10.1073/pnas.79.4.1154.
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Active proliferation of Rous sarcoma virus-infected, but not normal, chicken heart mesenchymal cells in culture medium of physiological composition.在生理成分培养基中，劳斯肉瘤病毒感染的鸡心脏间充质细胞（而非正常细胞）的活跃增殖。
Proc Natl Acad Sci U S A. 1980 Nov;77(11):6606-10. doi: 10.1073/pnas.77.11.6606.