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黄花蒿提取物对小鼠半乳糖诱导的氧化应激的保护作用。

Protective effect of Artemisia annua L. extract against galactose-induced oxidative stress in mice.

作者信息

Kim Mi Hye, Seo Ji Yeon, Liu Kwang Hyun, Kim Jong-Sang

机构信息

School of Food Science and Biotechnology, Kyungpook National University, Daegu, Republic of Korea.

College of Pharmacy, Kyungpook National University, Daegu, Republic of Korea.

出版信息

PLoS One. 2014 Jul 2;9(7):e101486. doi: 10.1371/journal.pone.0101486. eCollection 2014.

DOI:10.1371/journal.pone.0101486
PMID:24988450
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4079707/
Abstract

Artemisia annua L. (also called qinghao) has been well known as a source of antimalarial drug artemisinins. In addition, the herb was reported to have in vitro antioxidative activity. The present study investigated the protective effect of aqueous ethanol extract of Qinghao (AA extract) against D-galactose-induced oxidative stress in C57BL/6J mice. Feeding AA extract-containing diet lowered serum levels of malondialdehyde and 8-OH-dG that are biomarkers for lipid peroxidation and DNA damage, respectively. Furthermore, AA extract feeding enhanced the activity of NQO1, a typical antioxidant marker enzyme, in tissues such as kidney, stomach, small intestine, and large intestine. In conclusion, AA extract was found to have antioxidative activity in mouse model.

摘要

黄花蒿（也称为青蒿）作为抗疟药物青蒿素的来源而广为人知。此外，据报道该草药具有体外抗氧化活性。本研究调查了青蒿水乙醇提取物（AA提取物）对D-半乳糖诱导的C57BL/6J小鼠氧化应激的保护作用。喂食含AA提取物的饮食可降低血清丙二醛和8-羟基脱氧鸟苷水平，它们分别是脂质过氧化和DNA损伤的生物标志物。此外，喂食AA提取物可增强肾脏、胃、小肠和大肠等组织中典型抗氧化标记酶NQO1的活性。总之，在小鼠模型中发现AA提取物具有抗氧化活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb4b/4079707/721ad1ef3664/pone.0101486.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb4b/4079707/fcc3f109856b/pone.0101486.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb4b/4079707/9bde33f4dc51/pone.0101486.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb4b/4079707/51d22e35bc71/pone.0101486.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb4b/4079707/27f4cf223564/pone.0101486.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb4b/4079707/721ad1ef3664/pone.0101486.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb4b/4079707/fcc3f109856b/pone.0101486.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb4b/4079707/9bde33f4dc51/pone.0101486.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb4b/4079707/51d22e35bc71/pone.0101486.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb4b/4079707/27f4cf223564/pone.0101486.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb4b/4079707/721ad1ef3664/pone.0101486.g005.jpg

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