Department of Chemistry, Idaho State University, Pocatello, ID 83209, USA.
School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Korea.
Molecules. 2021 Nov 19;26(22):6995. doi: 10.3390/molecules26226995.
Diverse medicinal plants such as those from the genus have been employed globally for centuries by individuals belonging to different cultures. Universally, species have been used to remedy various maladies that range from simple fevers to malaria. A survey conducted by the World Health Organization (WHO) demonstrated that 80% of the global population is highly reliant on herbal medicine for their primary healthcare. WHO recommends artemisinin-based combination therapies (ACT) for the treatment of global diseases such as malaria. Artemisinin is a bioactive compound derived from leaves. It is a sesquiterpene endoperoxide with potent antimalarial properties. This review strives to instill natural products to chemists and others in diverse fields with a heterogeneous set of knowledge compiled from multifaceted researchers and organizations in literature. In particular, the various species and effective extraction, isolation, and characterization methodologies are discussed in detail. An in-depth investigation into the literature reveals that divergent species of exhibit a vast array of biological activities such as antimalarial, antitumor, and anti-inflammatory activities. There is substantial potential for bioactive compounds from to provide significant relief from differing human ailments, but more meticulous research in this field is needed.
不同的药用植物，如来自属的植物，在不同文化的人群中被全球使用了几个世纪。普遍地，物种被用于治疗从简单的发烧到疟疾等各种疾病。世界卫生组织（WHO）进行的一项调查表明，全球 80%的人口高度依赖草药来进行基本医疗保健。世界卫生组织建议使用青蒿素为基础的联合疗法（ACT）来治疗疟疾等全球疾病。青蒿素是一种从叶子中提取的生物活性化合物。它是一种具有强效抗疟性质的倍半萜过氧化物。本综述旨在向化学家及其他来自不同领域的人灌输天然产物的知识，这些知识是从文献中多方面的研究人员和组织收集的一组异构知识编译而成的。特别是，详细讨论了不同的物种和有效的提取、分离和特性鉴定方法。深入研究文献表明，不同的物种表现出广泛的生物活性，如抗疟、抗肿瘤和抗炎活性。来自的生物活性化合物有很大的潜力为不同的人类疾病提供显著的缓解，但在这一领域需要更细致的研究。
