自身免疫性疾病中的微小RNA
MicroRNAs in autoimmune diseases.
作者信息
Qu Zigang, Li Wenhui, Fu Baoquan
机构信息
State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Public Health of the Ministry of Agriculture, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China.
出版信息
Biomed Res Int. 2014;2014:527895. doi: 10.1155/2014/527895. Epub 2014 Jun 4.
Abstract
Autoimmune diseases (ADs) are featured by body's immune responses being directed towards its own specific target organs or multiple organ systems, causing persistent inflammation and consequent tissue damage. miRNAs are small noncoding RNAs in a size of approximately 22 nt that play important regulatory roles in many organisms by cleavage or translational inhibition of targeted mRNAs. Many miRNAs are reported to be differentially expressed in ADs and may play a pivotal role in regulating immune responses and autoimmunity. In this review, current research progress in the miRNAs in ADs was elucidated.
摘要
自身免疫性疾病（ADs）的特征是机体的免疫反应针对自身特定靶器官或多个器官系统，导致持续性炎症及随之而来的组织损伤。微小RNA（miRNAs）是一类大小约为22个核苷酸的小型非编码RNA，通过切割或抑制靶向mRNA的翻译在许多生物体中发挥重要的调节作用。据报道，许多miRNAs在自身免疫性疾病中差异表达，并可能在调节免疫反应和自身免疫中起关键作用。在本综述中，阐述了自身免疫性疾病中miRNAs的当前研究进展。
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