硫醇作为用于制备硫代羰基的合成子：硫醇的有氧氧化用于硫代酰胺的合成。
Thiol as a synthon for preparing thiocarbonyl: aerobic oxidation of thiols for the synthesis of thioamides.
作者信息
Wang Xi, Ji Miran, Lim Seungyeon, Jang Hye-Young
机构信息
Department of Energy Systems Research, Ajou University , Suwon 443-749, Korea.
出版信息
J Org Chem. 2014 Aug 1;79(15):7256-60. doi: 10.1021/jo501378v. Epub 2014 Jul 15.
PMID:24993111
Abstract
It is a constant challenge to develop an environmentally friendly, atom-economical, and step-economical method for the preparation of thioamides. Herein, we describe an oxidation method that affords the direct conversion of thiols to thioamides without the use of exogenous sulfur reagents. This is the first instance of a successful utilization of thiols as a synthon for the preparation of thioamides under economical conditions.
摘要
开发一种环境友好、原子经济且步骤经济的硫代酰胺制备方法一直是一项挑战。在此，我们描述了一种氧化方法，该方法可在不使用外源硫试剂的情况下将硫醇直接转化为硫代酰胺。这是在经济条件下成功将硫醇用作制备硫代酰胺的合成子的首个实例。
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