通过铜（II）催化炔酸酯与硫代酰胺的加成/氧化环化直接合成多取代的2-氨基噻吩
Direct synthesis of polysubstituted 2-aminothiophenes by Cu(II)-catalyzed addition/oxidative cyclization of alkynoates with thioamides.
作者信息
Ge Li-Shi, Wang Zheng-Lin, An Xing-Lan, Luo Xiaoyan, Deng Wei-Ping
机构信息
Shanghai Key Laboratory of Functional Materials Chemistry, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
出版信息
Org Biomol Chem. 2014 Nov 14;12(42):8473-9. doi: 10.1039/c4ob01534g.
PMID:25227952
Abstract
A facile and direct synthetic method was developed for the construction of structurally important 2-aminothiophenes in moderate to excellent yields (up to 91%), via Cu(II)-catalyzed addition/oxidative cyclization of readily available thioamides with alkynoates under an air atmosphere.
摘要
通过在空气氛围下，利用铜（II）催化易得的硫代酰胺与炔酸酯进行加成/氧化环化反应，开发了一种简便直接的合成方法，用于构建结构重要的2-氨基噻吩，产率中等至优异（高达91%）。
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