Lee Jessica L, Streuli Charles H
Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
J Cell Sci. 2014 Aug 1;127(Pt 15):3217-25. doi: 10.1242/jcs.146142. Epub 2014 Jul 2.
Cell polarity is characterised by differences in structure, composition and function between at least two poles of a cell. In epithelial cells, these spatial differences allow for the formation of defined apical and basal membranes. It has been increasingly recognised that cell-matrix interactions and integrins play an essential role in creating epithelial cell polarity, although key gaps in our knowledge remain. This Commentary will discuss the mounting evidence for the role of integrins in polarising epithelial cells. We build a model in which both inside-out signals to polarise basement membrane assembly at the basal surface, and outside-in signals to control microtubule apical-basal orientation and vesicular trafficking are required for establishing and maintaining the orientation of epithelial cell polarity. Finally, we discuss the relevance of the basal integrin polarity axis to cancer. This article is part of a Minifocus on Establishing polarity.
细胞极性的特征是细胞至少两个极在结构、组成和功能上存在差异。在上皮细胞中，这些空间差异使得明确的顶端膜和基底膜得以形成。尽管我们的知识仍存在关键空白，但人们越来越认识到细胞与基质的相互作用以及整合素在建立上皮细胞极性方面发挥着至关重要的作用。本述评将讨论整合素在极化上皮细胞中作用的越来越多的证据。我们构建了一个模型，其中在基底表面极化基底膜组装的由内向外信号以及控制微管顶端 - 基底方向和囊泡运输的由外向内信号对于建立和维持上皮细胞极性的方向都是必需的。最后，我们讨论基底整合素极性轴与癌症的相关性。本文是关于建立极性的迷你聚焦的一部分。
