Graur D, Shuali Y, Li W H
Department of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel.
J Mol Evol. 1989 Apr;28(4):279-85. doi: 10.1007/BF02103423.
The relative rates of point nucleotide substitution and accumulation of gap events (deletions and insertions) were calculated for 22 human and 30 rodent processed pseudogenes. Deletion events not only outnumbered insertions (the ratio being 7:1 and 3:1 for human and rodent pseudogenes, respectively), but also the total length of deletions was greater than that of insertions. Compared with their functional homologs, human processed pseudogenes were found to be shorter by about 1.2%, and rodent pseudogenes by about 2.3%. DNA loss from processed pseudogenes through deletion is estimated to be at least seven times faster in rodents than in humans. In comparison with the rate of point substitutions, the abridgment of pseudogenes during evolutionary times is a slow process that probably does not retard the rate of growth of the genome due to the proliferation of processed pseudogenes.
计算了22个人类和30个啮齿动物加工假基因的点核苷酸替换率和间隙事件（缺失和插入）的累积率。缺失事件不仅数量超过插入事件（人类和啮齿动物假基因的比例分别为7:1和3:1），而且缺失的总长度也大于插入的总长度。与它们的功能同源物相比，发现人类加工假基因短约1.2%，啮齿动物假基因短约2.3%。据估计，通过缺失导致的加工假基因的DNA丢失在啮齿动物中比在人类中至少快7倍。与点替换率相比，假基因在进化过程中的缩短是一个缓慢的过程，可能不会因为加工假基因的增殖而阻碍基因组的生长速度。
