超越 mRNA：非编码 RNA 在正常和异常造血中的作用。
Beyond mRNA: The role of non-coding RNAs in normal and aberrant hematopoiesis.
机构信息
Division of Hematology/Oncology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
SRI International, Biosciences Division, Menlo Park, CA, USA.
出版信息
Mol Genet Metab. 2017 Nov;122(3):28-38. doi: 10.1016/j.ymgme.2017.07.008. Epub 2017 Jul 25.
Abstract
The role of non-coding Ribonucleic Acids (ncRNAs) in biology is currently an area of intense focus. Hematopoiesis requires rapidly changing regulatory molecules to guide appropriate differentiation and ncRNA are well suited for this. It is not surprising that virtually all aspects of hematopoiesis have roles for ncRNAs assigned to them and doubtlessly much more await characterization. Stem cell maintenance, lymphoid, myeloid and erythroid differentiation are all regulated by various ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and various transposable elements within the genome. As our understanding of the many and complex ncRNA roles continues to grow, new discoveries are challenging the existing classification schemes. In this review we briefly overview the broad categories of ncRNAs and discuss a few examples regulating normal and aberrant hematopoiesis.
摘要
非编码核糖核酸（ncRNAs）在生物学中的作用目前是一个研究热点。造血需要快速变化的调节分子来指导适当的分化，ncRNA 非常适合这一点。毫不奇怪，造血的几乎所有方面都有分配给它们的 ncRNA 参与，而且毫无疑问还有更多有待描述。干细胞维持、淋巴样、髓样和红细胞分化都受到各种 ncRNA 的调节，包括 microRNAs（miRNAs）、长非编码 RNA（lncRNAs）和基因组内的各种转座元件。随着我们对 ncRNA 众多复杂作用的理解不断加深，新的发现正在挑战现有的分类方案。在这篇综述中，我们简要概述了 ncRNA 的广泛类别，并讨论了一些调节正常和异常造血的例子。
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