Kim Young Ho, Yun Cheolmin, Kim Jee Taek, Kim Seong-Woo, Oh Jaeryung, Huh Kuhl
Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
Department of Ophthalmology, Chung-Ang University Hospital, Seoul, Korea.
Br J Ophthalmol. 2014 Dec;98(12):1618-24. doi: 10.1136/bjophthalmol-2013-304765. Epub 2014 Jul 4.
To investigate the relationship between contrast sensitivity (CS) and retinal sensitivity (RS) assessed by microperimetry (MP) in diabetic retinopathy (DR) with clinically significant macular oedema (CSME).
A retrospective study was performed with 35 eyes of 35 patients with DR and CSME. Retinal thickness (RT) and MP were tested with the spectral SD-optical coherence topography/scanning laser ophthalmoscope system. Mean central RT at the fovea centre's 1 mm zone (CRT) and at the fixation centre's 1 mm zone (FCRT) was measured. RS was tested at the fixation centre, within 2° and 4° areas. CS was measured with six target sizes (6.3°, 4.0°, 2.5°, 1.6°, 1.0°, 0.64°) with a contrast glare tester.
The mean CRT and FCRT were 344.3±136.2 and 359.9±135.5 μm, respectively. Mean log CSs (-log10) with the six target sizes ranged from 0.19 to 1.32. The mean RS at the fixation centre, within 2°, and within 4° area were 8.51±4.81 dB, 8.58±3.88 dB and 9.22±3.56 dB, respectively. RS at all tested areas were significantly correlated to log CS with all target sizes (range, r=0.366-0.755; p=0.0001-0.030). CRT and FCRT were not significantly correlated to log CS or RS.
CS and RS showed moderately significant correlations in CSME. However, neither CS nor RS was correlated with RT in patients with CSME. It could be that CS and MP are complementary to each other and are useful tools in the evaluation of functional vision.
研究在患有具有临床意义的黄斑水肿（CSME）的糖尿病性视网膜病变（DR）中，通过微视野计（MP）评估的对比敏感度（CS）与视网膜敏感度（RS）之间的关系。
对35例患有DR和CSME的患者的35只眼睛进行了一项回顾性研究。使用光谱SD光学相干断层扫描/扫描激光检眼镜系统检测视网膜厚度（RT）和MP。测量黄斑中心凹中心1毫米区域（CRT）和注视中心1毫米区域（FCRT）的平均中央RT。在注视中心、2°和4°区域内测试RS。使用对比眩光测试仪，用六种目标大小（6.3°、4.0°、2.5°、1.6°、1.0°、0.64°）测量CS。
CRT和FCRT的平均值分别为344.3±136.2和359.9±135.5微米。六种目标大小的平均对数CS（-log10）范围为0.19至1.32。注视中心、2°和4°区域内的平均RS分别为8.51±4.81dB、8.58±3.88dB和9.22±3.56dB。所有测试区域的RS与所有目标大小的对数CS均显著相关（范围，r = 0.366 - 0.755；p = 0.0001 - 0.030）。CRT和FCRT与对数CS或RS均无显著相关性。
在CSME中，CS和RS显示出中度显著的相关性。然而，在患有CSME的患者中，CS和RS均与RT无关。可能是CS和MP相互补充，是评估功能性视力的有用工具。
