Musumeci G, Castrogiovanni P, Mazzone V, Szychlinska M A, Castorina S, Loreto C
University of Catania.
Eur J Histochem. 2014 Apr 15;58(2):2371. doi: 10.4081/ejh.2014.2371.
In this review article, we describe benefits and disadvantages of the established histochemical methods for studying articular cartilage tissue under normal, pathological and experimental conditions. We illustrate the current knowledge on cartilage tissue based on histological and immunohistochemical aspects, and in conclusion we provide a short overview on the degeneration of cartilage, such as osteoarthritis. Adult articular cartilage has low capacity to repair itself, and thus even minor injuries may lead to progressive damage and osteoarthritic joint degeneration, resulting in significant pain and disability. Numerous efforts have been made to implement the knowledge in the study of cartilage in the last years, and histochemistry proved to be an especially powerful tool to this aim.
在这篇综述文章中，我们描述了在正常、病理和实验条件下研究关节软骨组织的现有组织化学方法的优缺点。我们基于组织学和免疫组织化学方面阐述了关于软骨组织的当前知识，并且在结论部分，我们简要概述了软骨退变，如骨关节炎。成年关节软骨自身修复能力较低，因此即使是轻微损伤也可能导致渐进性损害和骨关节炎性关节退变，从而引起严重疼痛和功能障碍。在过去几年中，人们为将软骨研究方面的知识付诸实践付出了诸多努力，而组织化学被证明是实现这一目标的特别有力的工具。
