Liang Jun, Wang Yu, Li Hongyan, Liu Xuekui, Qiu Qinqin, Qi Lu
Cardiovasc Diabetol. 2014 Jul 8;13:107. doi: 10.1186/s12933-014-0107-x.
Neck circumference (NC) has been previously related to cardiometabolic risk factors. In this study we examined the association between NC and early stage atherosclerosis in Chinese adults.
The study samples were from a community-based health examination survey in central China. In total 2,318 men and women (18-64 y) were included in the final analyses. Carotid radial pulse wave velocity (crPWV), carotid femoral PWV (cfPWV), carotid artery dorsalis pedis PWV (cdPWV) and NC were measured.
After adjustment for age, sex, lipids, glucose, blood pressure, heart rate, body mass index (BMI), high NC was significantly associated with an increasing trend of cfPWV, cdPWV and crPWV (P = 0.001, 0.049, and 0.038; respectively). In addition, we found significant interaction between hypertension status and NC level in relation to cfPWV, adjusted for age, sex, BMI, fasting glucose, lipids and heart rate(P for interaction = 0.034). The associations between NC and cfPWV were significant (P = 0.02) among those with hypertension, but not significant among those without hypertension.
Our data showed that high NC was associated with an increased risk of early stage atherosclerosis in Chinese adults, independent of other metabolic risk factors. Hypertension might modify the association between NC and cfPWV.
颈围（NC）此前已被证明与心血管代谢危险因素相关。在本研究中，我们调查了中国成年人中颈围与早期动脉粥样硬化之间的关联。
研究样本来自中国中部一项基于社区的健康体检调查。最终分析纳入了总共2318名年龄在18 - 64岁之间的男性和女性。测量了颈股脉搏波速度（cfPWV）、颈桡脉搏波速度（crPWV）、颈背脉搏波速度（cdPWV）和颈围（NC）。
在对年龄、性别、血脂、血糖、血压、心率、体重指数（BMI）进行校正后，高颈围与cfPWV、cdPWV和crPWV的升高趋势显著相关（P分别为0.001、0.049和0.038）。此外，在对年龄、性别、BMI、空腹血糖、血脂和心率进行校正后，我们发现高血压状态与颈围水平在cfPWV方面存在显著交互作用（交互作用P = 0.034）。在高血压患者中，颈围与cfPWV之间的关联显著（P = 0.02），而在非高血压患者中不显著。
我们的数据表明，在中国成年人中，高颈围与早期动脉粥样硬化风险增加相关，且独立于其他代谢危险因素。高血压可能会改变颈围与cfPWV之间的关联。
