伊朗伊斯法罕人类免疫缺陷病毒感染且仅乙肝核心抗体阳性患者中的隐匿性乙型肝炎病毒感染
Occult hepatitis B virus infection among human immunodeficiency virus-infected patients with isolated hepatitis B core antibody in Isfahan, Iran.
作者信息
Khorvash Farzin, Javadi Abbasali, Tayeri Katayoun, Ataei Behrooz
机构信息
Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
J Res Med Sci. 2014 Mar;19(Suppl 1):S64-6.
BACKGROUND
Detection of hepatitis B virus (HBV) genomes without detectable hepatitis B surface antigen (HBs-Ag) is termed occult HBV infection (OHBV) that may be transmitted by blood transfusion or organ transplantation and has acute reactivation when an immunosuppressive status like human immunodeficiency virus (HIV) infection occurs. We aimed to evaluate OHBV in HIV-infected patients with isolated antibodies to hepatitis B core antigen (anti-HBc) in Isfahan, Iran.
MATERIALS AND METHODS
In a cross-sectional study during August-September 2011, serum samples from HIV-infected patients who attended Isfahan Consultation Center for Behavioral Diseases were tested for HBs-Ag and anti-HBc using ELISA method. HBV-deoxyribonucleic acid (DNA) was detected and quantified in plasma of HBs-Ag negative/anti-HBc positive subjects by real-time polymerase chain reaction.
RESULTS
From 64 HIV-positive individuals, 12 (18%) patients were HBs-Ag negative/anti-HBc positive, and from those 3 (25%) had detectable HBV-DNA in their plasma.
CONCLUSION
It seems that occult HBV might be assessed and be treated in HIV-infected patients.
背景
检测不到乙型肝炎表面抗原（HBs-Ag）但能检测到乙型肝炎病毒（HBV）基因组的情况被称为隐匿性HBV感染（OHBV），这种感染可能通过输血或器官移植传播，并且在发生免疫抑制状态如人类免疫缺陷病毒（HIV）感染时会出现急性再激活。我们旨在评估伊朗伊斯法罕地区HIV感染且仅乙肝核心抗体（抗-HBc）阳性患者中的OHBV情况。
材料与方法
在2011年8月至9月的一项横断面研究中，对前往伊斯法罕行为疾病咨询中心就诊的HIV感染患者的血清样本采用酶联免疫吸附测定（ELISA）法检测HBs-Ag和抗-HBc。通过实时聚合酶链反应对HBs-Ag阴性/抗-HBc阳性受试者的血浆进行HBV脱氧核糖核酸（DNA）检测和定量。
结果
在64名HIV阳性个体中，12名（18%）患者HBs-Ag阴性/抗-HBc阳性，其中3名（25%）患者血浆中可检测到HBV-DNA。
结论
似乎隐匿性HBV在HIV感染患者中可能需要进行评估和治疗。
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