Jaikanth Chandrasekaran, Gurumurthy Prema, Indhumathi Thillai, Cherian Kotturathu M
Department of Biochemical Pharmacology, Frontier Lifeline Hospital, Chennai, India.
Department of Biochemical Pharmacology, Frontier Lifeline Hospital, Chennai, India -
Minerva Endocrinol. 2017 Sep;42(3):280-289. doi: 10.23736/S0391-1977.16.02232-X. Epub 2014 Jul 8.
The widespread perception of obesity as a non-communicable disease is slowly giving way to the view of a contagious, communicable and potentially fatal condition. The downstream comorbidities associated with it are endless. Hence, the slogan "Fat To Fit" is being promoted worldwide. The view of white adipose tissue as a fat storage organ is now shifting to an endocrine organ. The secreted hormones, called adipocytokines, act in an autocrine, paracrine, and endocrine fashion. Like other hormones, they can have a positive as well as a negative influence over the body. Secreted frizzled-related protein 5 (SFRP5) is a recently identified novel adipocytokine which falls under the category of those adipokines which have a positive influence on the system. Plasma SFRP5 levels are significantly lower in patients with obesity, insulin resistance and diabetes, a condition which contributes to the major components of the metabolic syndrome and to other disease conditions like atherosclerosis, autoimmune disorders, etc. This review article focuses on the effects of SFRP5 on the major systems of the body and on its association with the Wnt signaling pathways.
肥胖作为一种非传染性疾病的普遍观念正逐渐让位于一种具有传染性、可传播且可能致命的疾病观念。与之相关的下游合并症层出不穷。因此，“从肥胖到健康”的口号正在全球范围内得到推广。白色脂肪组织作为脂肪储存器官的观念现在正转变为一种内分泌器官。分泌的激素，称为脂肪细胞因子，以自分泌、旁分泌和内分泌方式发挥作用。与其他激素一样，它们对身体可能产生积极和消极的影响。分泌型卷曲相关蛋白5（SFRP5）是最近发现的一种新型脂肪细胞因子，属于对该系统有积极影响的脂肪因子类别。肥胖、胰岛素抵抗和糖尿病患者的血浆SFRP5水平显著降低，这种情况导致了代谢综合征的主要成分以及其他疾病，如动脉粥样硬化、自身免疫性疾病等。这篇综述文章重点关注SFRP5对身体主要系统的影响及其与Wnt信号通路的关联。
